Evidence map›Paper›PMID 30467747›Full record

ArticleEnvironmental science and pollution research international2019

The modulatory role of low concentrations of bisphenol A on tamoxifen-induced proliferation and apoptosis in breast cancer cells.

Bin Huang, Nao Luo, Xinhao Wu, Zhixiang Xu, Xiaoxia Wang, Xuejun Pan

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Guava (Foods (Basel, Switzerland) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bin HuangFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China.
Nao LuoFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China.
Xinhao WuFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China.
Zhixiang XuFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China. xuzhixiangkmust@foxmail.com.
Xiaoxia WangFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China.
Xuejun PanFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China. xjpan@kmust.edu.cn.
Kunming University of Science and Technology · CN

Funding

National Natural Science Foundation of China 21567014Yunnan Province Scholarship Award 1319880239
6 · The paper itself

Abstract

Selective estrogen receptor modulators such as tamoxifen (TAM) significantly reduce the risks of developing estrogen receptor-positive (ER+) breast cancer. Low concentrations (nanomolar range) of bisphenol A (BPA) shows estrogenic effects and further promotes the proliferation of hormone-dependent breast cancer cells. However, whether or not BPA can influence TAM-treatment resistance in breast cancer has not drawn much attention. In the current study, low concentrations of BPA reduced TAM-induced cytotoxicity of MCF-7 cells, which was proved by the suppression of cell apoptosis, transition of cell cycle from G1 to S phase, and upregulation of cyclin D1 and ERα. Simultaneously, the mRNA levels of estrogen-related receptor γ (ERRγ) and its coactivators, peroxisome proliferation-activated receptor γ coactivator-1α (PGC-1α), and PGC-1β, were increased. However, the similar effects were not observed in MDA-MB-231 cells. Our results indicated that low concentrations of BPA decreased the sensitivity of TAM in MCF-7 cells rather than in MDA-MB-231 cells. These different actions likely involved the interaction of relative receptors and coactivators. This study provided a possible support that the exposure of BPA in environmental media may potentially induce TAM resistance to breast cancer treatment.

Indexed as

ApoptosisBenzhydryl CompoundsBisphenol A CompoundsBreast NeoplasmsCell CycleCell Line, TumorCell ProliferationCyclin D1Dose-Response Relationship, DrugEstrogen Receptor alphaEstrogensFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCCND1 protein, humanCyclin D1ESR1 protein, humanEstrogen Receptor alphaEstrogensPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenolsPPARGC1A protein, humanSelective Estrogen Receptor ModulatorsTamoxifenTFF1 protein, humanTrefoil Factor-1Bisphenol ABreast cancer cellsCell viabilityEstrogen-related receptorsTamoxifen

Identifiers

PMID30467747
OpenAlexW2901729162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.