Evidence map›Paper›PMID 30467730›Full record

ArticleAMB Express2018

Expression and regulation of phenol-soluble modulins and enterotoxins in foodborne Staphylococcus aureus.

Xiaoxiao Wu, Miao Yang, Xin Fang, Shiqi Zhen, Jie Zhang, Xiangying Yang, Ling Qiao, Yang Yang, Chi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoxiao WuNational Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, No. 3 Jialingjiang East Street, Nanjing, 210019, China.
Miao YangNational Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, No. 3 Jialingjiang East Street, Nanjing, 210019, China.
Xin FangNational Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, No. 3 Jialingjiang East Street, Nanjing, 210019, China.
Shiqi ZhenJiangsu Provincial Center for Disease Control and Prevention, No. 172 Jiangsu Street, Nanjing, 210009, China.
Jie ZhangBeijing Entry-Exit Inspection and Quarantine Bureau Inspection and Quarantine Technical Center, No. 6 Tianshuiyuan Street, Chaoyang District, Beijing, 100026, China.
Xiangying YangBeijing Entry-Exit Inspection and Quarantine Bureau Inspection and Quarantine Technical Center, No. 6 Tianshuiyuan Street, Chaoyang District, Beijing, 100026, China.
Ling QiaoNational Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, No. 3 Jialingjiang East Street, Nanjing, 210019, China.
Yang YangNational Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, No. 3 Jialingjiang East Street, Nanjing, 210019, China.
Chi ZhangNational Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, No. 3 Jialingjiang East Street, Nanjing, 210019, China. 382951112@qq.com.

Funding

National Key R&D Program of China 2017YFF0211201National Key R&D Program of China 2018YFF0215200Science and Technology Program of Nanjing, China 201716005Science & Technology Project of China General Administration of Quality Supervision, Inspection and Quarantine 2015QK055Science & Technology Project of Jiangsu Quality and Technical Supervision Bureau KJ185613
6 · The paper itself

Abstract

Although high levels of staphylococcal phenol-soluble modulins (PSMs) in clinical methicillin-resistant Staphylococcus aureus (MRSA) has been shown to correlate with bacterial virulence, the PSMs expression in foodborne Staphylococcus aureus (S. aureus), as well as its association with staphylococcal food poisoning (SFP) was not yet clear. We collected a panel of 350 foodborne and 127 clinic-derived S. aureus strains and compared their PSMs expression. Overall, foodborne strains exhibited higher PSMs than clinical isolates, indicating a potential pathological significance of PSMs in staphylococcal food contamination. Furthermore, PSMs expression and staphylococcal enterotoxins (SEs) levels in relation to antibiotic sensitive and resistant strains were analysed. While the co-expression of PSMs and SEs was confirmed, one typical foodborne strain simultaneously yielding PSMs, SEB and SED was selected. By comparing this wildtype strain to a series of gene-deficient mutants, we concluded that PSMs and SEs expressions both relied on staphylococcal accessory regulator A initiation in the early stage of accessory gene regulator control, yet their succedent regulations differentiated to RNAIII-dependent and independent, respectively. These data provided preliminary insight into PSMs and SEs expression in foodborne S. aureus, and may guide the further studies on PSMs effects in SFP.

Indexed as

Co-expressionFoodbornePhenol-soluble modulinStaphylococcal enterotoxinStaphylococcus aureus

Identifiers

PMID30467730
PMCPMC6250609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.