Evidence map›Paper›PMID 30467683›Full record

ArticleRadiological physics and technology2019

Early detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) at 7T-MRI.

Shigeyoshi Saito, Yusuke Takahashi, Akiko Ohki, Yasunori Shintani, Takahiro Higuchi

Abstract read
PubMed Publisher
In one paragraph

Article in Radiological physics and technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Inverting CEST orMagnetic resonance in medicine · 2026
    Article
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  9. Review
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  11. Review
  12. Review
  13. Creatine Chemical Exchange Saturation Transfer (Cr-CEST) Imaging Can Evaluate Cisplatin-induced Testicular Damage.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Shigeyoshi SaitoDivision of Health Sciences, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka, 560-0871, Japan. saito@sahs.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-5100-9561
Yusuke TakahashiDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Akiko OhkiDepartment of Biomedical Imaging, National Cardiovascular and Cerebral Research Center, Suita, Osaka, 565-8565, Japan.
Yasunori ShintaniDepartment of Medical Biochemistry, Osaka University Graduate School of Frontier Bioscience, Suita, Osaka, 565-0871, Japan.
Takahiro HiguchiDepartment of Biomedical Imaging, National Cardiovascular and Cerebral Research Center, Suita, Osaka, 565-8565, Japan.
National Cerebral and Cardiovascular Center · JPThe University of Osaka · JPUniversity of Würzburg · DE

Funding

the Japan Society for the Promotion of Science 15K21774the Japan Society for the Promotion of Science 16K090170
6 · The paper itself

Abstract

This study aimed to use chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) at 7T-MRI for early detection of intracerebral lactate in a mitochondrial disease model without brain lesions. We considered Ndufs4-knockout (KO) mice as Leigh syndrome models and wild-type (WT) mice as control mice. Brain MRI and

Indexed as

Magnetic Resonance ImagingAnimalsDisease Models, AnimalLactatesMagnetic Resonance SpectroscopyMiceMitochondrial DiseasesTime FactorsLactatesChemical exchange saturation transferMagnetic resonance imagingMagnetic resonance spectroscopyMitochondrial disease

Identifiers

PMID30467683
OpenAlexW2901684545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.