Evidence map›Paper›PMID 30467678›Full record

ArticleIntensive care medicine2018

Development of an ICU discharge instrument predicting psychological morbidity: a multinational study.

A Milton, A Schandl, I W Soliman, K Meijers, M van den Boogaard, I M Larsson, C Brorsson, U Östberg, M Oxenbøll-Collet, J Savilampi and 3 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02679157 (Prognostication of Need for Rehabilitation and Special Support in ICU Survivors. Two Studies Prognosticating Adverse Physical or Psychological Outcome), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02679157 completednot on this map

Prognostication of Need for Rehabilitation and Special Support in ICU Survivors. Two Studies Prognosticating Adverse Physical or Psychological Outcome

TypeobservationalSponsorKarolinska University HospitalRan2016 to 2016Enrolled573ConditionsPhysical Disability, Depression, Posttraumatic Stress Disorder, Anxiety
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 3 countries.

A MiltonDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. anna.milton@sll.se.ORCID http://orcid.org/0000-0002-5787-7167
A SchandlDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
I W SolimanDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
K MeijersDepartment of Anaesthesiology and Intensive Care, Sodersjukhuset, Stockholm, Sweden.
M van den BoogaardDepartment of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
I M LarssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
C BrorssonDepartment of Surgery and Perioperative Science, Umeå University, Umeå, Sweden.
U ÖstbergDepartment of Anaesthesiology and Intensive Care, Östersund Hospital, Östersund, Sweden.
M Oxenbøll-ColletDepartment of Intensive Care, Rigshospitalet Copenhagen, Copenhagen, Denmark.
J SavilampiDepartment of Anaesthesiology and Intensive Care, Örebro University Hospital, Örebro, Sweden.
S PaskinsDepartment of Intensive Care, Odense University Hospital, Odense, Denmark.
M BottaiInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
P V SackeyDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SEOdense University Hospital · DKÖrebro University Hospital · SEÖstersunds Hospital · SERadboud University Nijmegen · NLRigshospitalet · DKStockholm South General Hospital · SEUmeå University · SEUppsala University · SEUtrecht University · NL

Funding

Stiftelsen Olle Engkvist Byggmästare 00000Stockholms Läns Landsting 20140083
6 · The paper itself

Abstract

purposeTo develop an instrument for use at ICU discharge for prediction of psychological problems in ICU survivors.

methodsMultinational, prospective cohort study in ten general ICUs in secondary and tertiary care hospitals in Sweden, Denmark and the Netherlands. Adult patients with an ICU stay ≥ 12 h were eligible for inclusion. Patients in need of neurointensive care, with documented cognitive impairment, unable to communicate in the local language, without a home address or with more than one limitation of therapy were excluded. Primary outcome was psychological morbidity 3 months after ICU discharge, defined as Hospital Anxiety and Depression Scale (HADS) subscale score ≥ 11 or Post-traumatic Stress Symptoms Checklist-14 (PTSS-14) part B score > 45.

resultsA total of 572 patients were included and 78% of patients alive at follow-up responded to questionnaires. Twenty percent were classified as having psychological problems post-ICU. Of 18 potential risk factors, four were included in the final prediction model after multivariable logistic regression analysis: symptoms of depression [odds ratio (OR) 1.29, 95% confidence interval (CI) 1.10-1.50], traumatic memories (OR 1.44, 95% CI 1.13-1.82), lack of social support (OR 3.28, 95% CI 1.47-7.32) and age (age-dependent OR, peak risk at age 49-65 years). The area under the receiver operating characteristics curve (AUC) for the instrument was 0.76 (95% CI 0.70-0.81).

conclusionsWe developed an instrument to predict individual patients' risk for psychological problems 3 months post-ICU, http://www.imm.ki.se/biostatistics/calculators/psychmorb/ . The instrument can be used for triage of patients for psychological ICU follow-up.

trial registrationThe study was registered at clinicaltrials.gov, NCT02679157.

Indexed as

Intensive Care UnitsPatient DischargeAgedAnxietyCohort StudiesDenmarkDepressionFemaleHumansMaleMiddle AgedNetherlandsRisk AssessmentRisk FactorsStress Disorders, Post-TraumaticSurveys and QuestionnairesAnxietyDepressionFollow-upIntensive carePICSPost-traumatic stress

Identifiers

PMID30467678
PMCPMC6280826
OpenAlexW2901255610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.