Evidence map›Paper›PMID 30467620›Full record

ReviewInflammopharmacology2019

Stress as an immunomodulator: liver X receptors maybe the answer.

Issam Nessaibia, Allan Fouache, Jean-Marc A Lobaccaro, Abdelkrim Tahraoui, Amalia Trousson, Maâmar Souidi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Issam NessaibiaCNRS UMR 6293, Laboratory GReD, INSERM U 1103, Clermont Auvergne University, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France. issamland@yahoo.fr.ORCID http://orcid.org/0000-0002-2597-1183
Allan FouacheCNRS UMR 6293, Laboratory GReD, INSERM U 1103, Clermont Auvergne University, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France.
Jean-Marc A LobaccaroCNRS UMR 6293, Laboratory GReD, INSERM U 1103, Clermont Auvergne University, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France.
Abdelkrim TahraouiLaboratory of Applied Neuro-Endocrinology, Department of Biology, Badji-Mokhtar University, Annaba, Algeria.
Amalia TroussonCNRS UMR 6293, Laboratory GReD, INSERM U 1103, Clermont Auvergne University, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France.
Maâmar SouidiInstitut de radioprotection et de sûreté nucléaire, Direction de la radioprotection de l'homme, IRSN, Fontenay-aux-Roses Cedex, France.
Centre National de la Recherche Scientifique · FRBadji Mokhtar-Annaba University · DZInstitut de Radioprotection et de Sûreté Nucléaire · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system. Stress modifies the Th1/Th2 balance via the HPA axis and a set of immune mediators. This will make the body more vulnerable to external infections in a scientific way while others claim the opposite, stress could be considered immune stimulatory. The development of synthetic LXR ligands such as T0901317 and GW3965 as well as an understanding of the direct involvement of these receptors in the regulation of proopiomelanocortin (POMC) gene expression and indirectly by producing a variety of cytokines in a stressor response, will open in the near future new therapeutic methods against the undesirable effects of stress on the behavior of the immune system.

Indexed as

AnimalsCytokinesHumansImmunologic FactorsLiver X ReceptorsStress, PhysiologicalStress, PsychologicalCytokinesImmunologic FactorsLiver X ReceptorsHypothalamus pituitary adrenal (HPA)Infectious diseasesLiver X receptorsStressTh1/Th2 balance

Identifiers

PMID30467620
OpenAlexW2901656646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.