ArticleFrontiers in plant science2018
Ethylene Receptors, CTRs and EIN2 Target Protein Identification and Quantification Through Parallel Reaction Monitoring During Tomato Fruit Ripening.
Article in Frontiers in plant science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Black flesh disorder in mango: a chilling injury symptom increased by early harvest and low storage temperature and reduced by 1-methylcyclopropene.Journal of the science of food and agriculture · 2026Article
- Ethylene networking in fruit ripening: molecular mechanisms, hormone crosstalk, climate interactions, and postharvest management.Plant cell reports · 2026Review
- Regulation of the growth-to-ripening transition in tomato fruits by energy charge involving SlATP-PRT and SlAPRT1.Molecular horticulture · 2026Article
- CpERF-WRI1 Manipulates Ethylene Sensing by Regulating the Expression of CpERS1 and Fruit Ripening in Papaya.Plant biotechnology journal · 2026Article
- SlERF-RD1 acts as a developmental coordinator integrating plant canopy architecture and the ethylene-mediated ripening cascade in tomato.Plant cell reports · 2026Article
- Ethylene signaling and metabolite reprogramming in salt tolerance of Triticum aestivum.Scientific reports · 2026Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- Transcription factor PbrERF114 is involved in the regulation of ethylene synthesis during pear fruit ripening.Molecular horticulture · 2024Article
- Functions of membrane proteins in regulating fruit ripening and stress responses of horticultural crops.Molecular horticulture · 2024Review
- The hormone regulatory mechanism underlying parthenocarpic fruit formation in tomato.Frontiers in plant science · 2024Review
- Targeted system approach to ethylene biosynthesis and signaling of a heat tolerant tomato cultivar; the impact of growing season on fruit ripening.Frontiers in plant science · 2023Article
- Tuning heterologous glucan biosynthesis in yeast to understand and exploit plant starch diversity.BMC biology · 2022Article
- Salicylic acid modulates ACS, NHX1, sos1 and HKT1;2 expression to regulate ethylene overproduction and NaPlant signaling & behavior · 2021Article
- The interplay between ABA/ethylene and NAC TFs in tomato fruit ripening: a review.Plant molecular biology · 2021Review
- Proteomics Data Analysis for the Identification of Proteins and Derived Proteotypic Peptides of Potential Use as Putative Drought Tolerance Markers forInternational journal of molecular sciences · 2021Article
- Characterization of Two Ethephon-InducedGenes · 2021Article
- Hydrogen gas alleviates postharvest senescence of cut rose 'Movie star' by antagonizing ethylene.Plant molecular biology · 2020Article
- Systematic Multi-Omics Integration (MOI) Approach in Plant Systems Biology.Frontiers in plant science · 2020Review
- Proteomic Changes in Antioxidant System in Strawberry During Ripening.Frontiers in plant science · 2020Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Ethylene, the plant ripening hormone of climacteric fruit, is perceived by ethylene receptors which is the first step in the complex ethylene signal transduction pathway. Much progress has been made in elucidating the mechanism of this pathway, but there is still a lot to be done in the proteomic quantification of the main proteins involved, particularly during fruit ripening. This work focuses on the mass spectrometry based identification and quantification of the ethylene receptors (ETRs) and the downstream components of the pathway, CTR-like proteins (CTRs) and ETHYLENE INSENSITIVE 2 (EIN2). We used tomato as a model fruit to study changes in protein abundance involved in the ethylene signal transduction during fruit ripening. In order to detect and quantify these low abundant proteins located in the membrane of the endoplasmic reticulum, we developed a workflow comprising sample fractionation and MS analysis using parallel reaction monitoring. This work shows the feasibility of the identification and absolute quantification of all seven ethylene receptors, three out of four CTRs and EIN2 in four ripening stages of tomato. In parallel, gene expression was analyzed through real-time qPCR. Correlation between transcriptomic and proteomic profiles during ripening was only observed for three of the studied proteins, suggesting that the other signaling proteins are likely post-transcriptionally regulated. Based on our quantification results we were able to show that the protein levels of SlETR3 and SlETR4 increased during ripening, probably to control ethylene sensitivity. The other receptors and CTRs showed either stable levels that could sustain, or decreasing levels that could promote fruit ripening.
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