Evidence map›Paper›PMID 30467428›Full record

ReviewNature reviews. Molecular cell biology2019

Ribosome assembly coming into focus.

Sebastian Klinge, John L Woolford

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers.

0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

313 citing papers in PubMed, 474 citations in OpenAlex.

  1. Exchange dynamics and kinetic control of gene regulation complexes.Nature reviews. Molecular cell biology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. RiboScreenBiomedicines · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Perturbation of RNA homeostasis impairs mitochondrial respiration during poxvirus infection through excess RNA accumulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. Nucleolar Dynamics During Oogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Ribosome biogenesis bottlenecks reveal vulnerabilities in cancer.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

253 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sebastian KlingeLaboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY, USA. klinge@rockefeller.edu.
John L WoolfordDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA. jw17@andrew.cmu.edu.ORCID http://orcid.org/0000-0002-7553-7043
Carnegie Mellon University · USRockefeller University · US

Funding

YEAST RIBOSOME BIOGENESISR01GM028301 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI WOOLFORD, JOHN L. · 1985 to 2025
$8.4M
Trapping and reconstituting early stages of eukaryotic ribosome assemblyDP2GM123459 · NIGMS · ROCKEFELLER UNIVERSITY · PI KLINGE, SEBASTIAN · 2016 to 2016
$2.5M
NIGMS NIH HHS DP2 GM123459NIGMS NIH HHS R01 GM028301
6 · The paper itself

Abstract

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have identified most of the factors that participate in this complex pathway and have generated models for the mechanisms driving the assembly. More recently, the publication of numerous cryo-electron microscopy structures of yeast ribosome assembly intermediates has provided near-atomic resolution snapshots of ribosome precursor particles. Satisfyingly, these structural data support the genetic and biochemical models and provide additional mechanistic insight into ribosome assembly. In this Review, we discuss the mechanisms of assembly of the yeast small ribosomal subunit and large ribosomal subunit in the nucleolus, nucleus and cytoplasm. Particular emphasis is placed on concepts such as the mechanisms of RNA compaction, the functions of molecular switches and molecular mimicry, the irreversibility of assembly checkpoints and the roles of structural and functional proofreading of pre-ribosomal particles.

Indexed as

AnimalsCell NucleusCryoelectron MicroscopyCytoplasmHumansRibosome SubunitsRNARNA

Identifiers

PMID30467428
PMCPMC7725133
OpenAlexW2901941802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.