ArticleScientific reports2018
The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances.Cellular and molecular neurobiology · 2026Review
- Hemolymph microbiota and immune effectors' expressions driven by geographical rearing acclimation of the aquacultured Penaeus stylirostris.Animal microbiome · 2025Article
- Actively expressed microbiota in mucosal biopsies of treatment-naïve ulcerative colitis patients.Gut microbes reports · 2025Article
- Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome.Clinical and experimental gastroenterology · 2025Article
- The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia.Journal of gastroenterology · 2024Article
- Constituents of stable commensal microbiota imply diverse colonic epithelial cell reactivity in patients with ulcerative colitis.Gut pathogens · 2024Article
- Relationship between mucosa-associated gut microbiota and human diseases.Biochemical Society transactions · 2022Review
- Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients.Bioengineered · 2021Article
- Characteristics of mouse intestinal microbiota during acute liver injury and repair following 50% partial hepatectomy.Experimental and therapeutic medicine · 2021Article
- Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis.Scientific reports · 2021Article
- Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease.Microorganisms · 2021Review
- Alteration and the Function of Intestinal Microbiota in High-Fat-Diet- or Genetics-Induced Lipid Accumulation.Frontiers in microbiology · 2021Article
- Ulcerative colitis: Recent advances in the understanding of disease pathogenesis.F1000Research · 2020Review
- Article
- Pain after upper limb surgery under peripheral nerve block is associated with gut microbiome composition and diversity.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
8 authors.
Funding
Abstract
Active microbes likely have larger impact on gut health status compared to inactive or dormant microbes. We investigate the composition of active and total mucosal microbiota of treatment-naïve ulcerative colitis (UC) patients to determine the microbial picture at the start-up phase of disease, using both a 16S rRNA transcript and gene amplicon sequencing. DNA and RNA were isolated from the same mucosal colonic biopsies. Our aim was to identify active microbial members of the microbiota in early stages of disease and reveal which members are present, but do not act as major players. We demonstrated differences in active and total microbiota of UC patients when comparing inflamed to non-inflamed tissue. Several taxa, among them the Proteobacteria phyla and families therein, revealed lower transcriptional activity despite a high presence. The Bifidobacteriaceae family of the Actinobacteria phylum showed lower abundance in the active microbiota, although no difference in presence was detected. The most abundant microbiota members of the inflamed tissue in UC patients were not the most active. Knowledge of active members of microbiota in UC patients could enhance our understanding of disease etiology. The active microbial community composition did not deviate from the total when comparing UC patients to non-IBD controls.
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