Evidence map›Paper›PMID 30467376›Full record

ArticleTranslational psychiatry2018

Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample.

Sarah Wilker, Anna Schneider, Daniela Conrad, Anett Pfeiffer, Christina Boeck, Birke Lingenfelder, Virginie Freytag, Vanja Vukojevic, Christian Vogler, Annette Milnik and 5 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Sarah WilkerClinical & Biological Psychology, Ulm University, Ulm, Germany. sarah.wilker@uni-bielefeld.de.
Anna SchneiderClinical & Biological Psychology, Ulm University, Ulm, Germany. anna.schneider@uni-ulm.de.
Daniela ConradClinical & Biological Psychology, Ulm University, Ulm, Germany. daniela.conrad@uni-konstanz.de.
Anett PfeifferClinical Psychology and Neuropsychology, University of Konstanz, Konstanz, Germany.
Christina BoeckClinical & Biological Psychology, Ulm University, Ulm, Germany.
Birke LingenfelderClinical Psychology and Neuropsychology, University of Konstanz, Konstanz, Germany.
Virginie FreytagDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Vanja VukojevicDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Christian VoglerDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-3922-109X
Annette MilnikDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-3933-3289
Andreas PapassotiropoulosDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Dominique J-F de QuervainTransfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.
Thomas ElbertClinical Psychology and Neuropsychology, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0003-1332-4939
Stephan KolassaSAP Switzerland AG, Tägerwilen, Switzerland.ORCID http://orcid.org/0000-0001-9393-0765
Iris-Tatjana KolassaClinical & Biological Psychology, Ulm University, Ulm, Germany. iris.kolassa@uni-ulm.de.ORCID http://orcid.org/0000-0001-7847-1847
University of Basel · CHUniversität Ulm · DEUniversity of Konstanz · DESystems, Applications & Products in Data Processing (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The probability to develop posttraumatic stress disorder (PTSD), characterized by vivid, intrusive emotional memories of the encountered traumatic events, depends - among other factors - on the number of previous traumatic experiences (traumatic load) and individual genetic vulnerability. So far, our knowledge regarding the biological underpinnings of PTSD is relatively sparse. Genome-wide association studies (GWAS) followed by independent replication might help to discover novel, so far unknown biological mechanisms associated with the development of traumatic memories. Here, a GWAS was conducted in N = 924 Northern Ugandan rebel war survivors and identified seven suggestively significant single nucleotide polymorphisms (SNPs; p ≤ 1 × 10

Indexed as

GenocideGenome-Wide Association StudyOutcome Assessment, Health CareStress Disorders, Post-TraumaticSurvivorsWar ExposureAdultEmotionsFemaleFollow-Up StudiesHumansImplosive TherapyMaleMemoryNarrative TherapyPolymorphism, Single Nucleotide

Identifiers

PMID30467376
PMCPMC6250662
OpenAlexW2900535092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.