Evidence map›Paper›PMID 30467368›Full record

ArticleScientific reports2018

A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain.

Veronika Khariv, Cigdem Acioglu, Li Ni, Ayomi Ratnayake, Lun Li, Yuan-Xiang Tao, Robert F Heary, Stella Elkabes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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  4. Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  5. Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Veronika KharivDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA.
Cigdem AciogluDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA.
Li NiDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA.
Ayomi RatnayakeDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA.
Lun LiDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA.
Yuan-Xiang TaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, 07103, USA.
Robert F HearyDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA.
Stella ElkabesDepartment of Neurological Surgery, The Reynolds Family Spine Laboratory, New Jersey Medical School, Rutgers,The State University of New Jersey, Newark, NJ, 07103, USA. elkabest@njms.rutgers.edu.
Neurological Surgery · USRutgers, The State University of New Jersey · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier studies on genetically modified mice indicated that plasma membrane calcium ATPase 2 (PMCA2), a calcium extrusion pump, plays a novel and sex-dependent role in mechanical pain responses: female, but not male, PMCA2

Indexed as

AnimalsDisease Models, AnimalEstradiolEstrogen Receptor alphaFemaleGene Knockout TechniquesInjections, SpinalMaleMiceOrchiectomyOvariectomyPainPain ThresholdPlasma Membrane Calcium-Transporting ATPasesSex CharacteristicsSignal TransductionAtp2b2 protein, mouseEstradiolEstrogen Receptor alphaPlasma Membrane Calcium-Transporting ATPases

Identifiers

PMID30467368
PMCPMC6250714
OpenAlexW2901417246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.