ArticleScientific reports2018
Redirecting Primary Metabolism to Boost Production of Tyrosine-Derived Specialised Metabolites in Planta.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Advances in Betalain Biosynthesis and Metabolic Engineering for Sustainable Natural Pigment Production.Biotech (Basel (Switzerland)) · 2026Review
- Chassis selection and metabolic fine-tuning enable efficient in planta betalain production.Plant physiology · 2026Article
- Effect of Weather Conditions on Phytochemical Profiles in Organically Grown Cowpea (Plants (Basel, Switzerland) · 2025Article
- In planta complementation of the betalain biosynthetic pathway with a bacterial dioxygenase.PloS one · 2025Article
- Multiplex Expression Cassette Assembly: A flexible and versatile method for building complex genetic circuits in conventional vectors.Plant biotechnology journal · 2024Article
- Establishment of Betalain-Producing Cell Line and Optimization of Pigment Production in Cell Suspension Cultures ofPlants (Basel, Switzerland) · 2024Article
- Flower color modification in Torenia fournieri by genetic engineering of betacyanin pigments.BMC plant biology · 2024Article
- Advancing Engineered Plant Living Materials through Tobacco BY-2 Cell Growth and Transfection within Tailored Granular Hydrogel Scaffolds.ACS central science · 2024Article
- Engineering a complex, multiple enzyme-mediated synthesis of natural plant pigments in the silkworm,Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative Metabolomic and Transcriptomic Analyses of Phytochemicals in Two Elite Sweet Potato Cultivars for Table Use.Molecules (Basel, Switzerland) · 2022Article
- Regulation Mechanism of Plant Pigments Biosynthesis: Anthocyanins, Carotenoids, and Betalains.Metabolites · 2022Review
- Biotechnological advances for improving natural pigment production: a state-of-the-art review.Bioresources and bioprocessing · 2022Review
- A Genome-Wide Identification Study Reveals ThatGenes · 2021Article
- Anthocyanin synthesis potential in betalain-producing Caryophyllales plants.Journal of plant research · 2021Article
- A chromosome-scale genome sequence of pitaya (Hylocereus undatus) provides novel insights into the genome evolution and regulation of betalain biosynthesis.Horticulture research · 2021Article
- MycoRed: Betalain pigments enable in vivo real-time visualisation of arbuscular mycorrhizal colonisation.PLoS biology · 2021Article
- Engineering Betalain Biosynthesis in Tomato for High Level Betanin Production in Fruits.Frontiers in plant science · 2021Article
- Combined Transcriptome and Metabolome analysis of Pitaya fruit unveiled the mechanisms underlying Peel and pulp color formation.BMC genomics · 2020Article
- Evolution of l-DOPA 4,5-dioxygenase activity allows for recurrent specialisation to betalain pigmentation in Caryophyllales.The New phytologist · 2020Article
- Harnessing evolutionary diversification of primary metabolism for plant synthetic biology.The Journal of biological chemistry · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
L-Tyrosine-derived specialized metabolites perform many important functions in plants, and have valuable applications in human health and nutrition. A necessary step in the overproduction of specialised tyrosine-derived metabolites in planta is the manipulation of primary metabolism to enhance the availability of tyrosine. Here, we utilise a naturally occurring de-regulated isoform of the key enzyme, arogenate dehydrogenase, to re-engineer the interface of primary and specialised metabolism, to boost the production of tyrosine-derived pigments in a heterologous plant host. Through manipulation of tyrosine availability, we report a 7-fold increase in the production of tyrosine-derived betalain pigments, with an upper range of 855 mg·kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.