Evidence map›Paper›PMID 30467297›Full record

ArticleInternational journal of molecular sciences2018

A Rapid Method for the Detection of Sarcosine Using SPIONs/Au/CS/SOX/NPs for Prostate Cancer Sensing.

Dagmar Uhlirova, Martina Stankova, Michaela Docekalova, Bozena Hosnedlova, Marta Kepinska, Branislav Ruttkay-Nedecky, Josef Ruzicka, Carlos Fernandez, Halina Milnerowicz, Rene Kizek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Dagmar UhlirovaDepartment of Research and Development, Prevention Medicals, Tovarni 342, 742 13 Studenka-Butovice, Czech Republic. dagmar.uhlirova@seznam.cz.
Martina StankovaDepartment of Research and Development, Prevention Medicals, Tovarni 342, 742 13 Studenka-Butovice, Czech Republic. MartStan@seznam.cz.
Michaela DocekalovaDepartment of Research and Development, Prevention Medicals, Tovarni 342, 742 13 Studenka-Butovice, Czech Republic. MichaelaDocekalova@seznam.cz.
Bozena HosnedlovaDepartment of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 612 42 Brno, Czech Republic. bozena.hosnedlova@post.cz.
Marta KepinskaDepartment of Biomedical and Environmental Analyses, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland. zalewska.m@gmail.com.ORCID 0000-0002-0935-5663
Branislav Ruttkay-NedeckyDepartment of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 612 42 Brno, Czech Republic. brano.ruttkay@seznam.cz.
Josef RuzickaDepartment of Research and Development, Prevention Medicals, Tovarni 342, 742 13 Studenka-Butovice, Czech Republic. ruzicka.josef@iol.cz.
Carlos FernandezSchool of Pharmacy and Life Sciences, Robert Gordon University, Garthdee Road, Aberdeen AB10 7QB, UK. c.fernandez@rgu.ac.uk.
Halina MilnerowiczDepartment of Biomedical and Environmental Analyses, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland. halina.milnerowicz@umed.wroc.pl.
Rene KizekDepartment of Research and Development, Prevention Medicals, Tovarni 342, 742 13 Studenka-Butovice, Czech Republic. kizek@sci.muni.cz.
University of Veterinary Sciences Brno · CZWroclaw Medical University · PLRobert Gordon University · GB

Funding

Sarcotest 165/2016
6 · The paper itself

Abstract

backgroundSarcosine is an amino acid that is formed by methylation of glycine and is present in trace amounts in the body. Increased sarcosine concentrations in blood plasma and urine are manifested in sarcosinemia and in some other diseases such as prostate cancer. For this purpose, sarcosine detection using the nanomedicine approach was proposed. In this study, we have prepared superparamagnetic iron oxide nanoparticles (SPIONs) with different modified surface area. Nanoparticles (NPs) were modified by chitosan (CS), and sarcosine oxidase (SOX). SPIONs without any modification were taken as controls.

Indexed as

Biomarkers, TumorChitosanEscherichia coliFerric CompoundsGoldHemolysisHorseradish PeroxidaseHumansHydrogen-Ion ConcentrationLimit of DetectionMagnetite NanoparticlesMaleOxidation-ReductionParticle SizePrecision MedicineProstatic NeoplasmsBiomarkers, TumorChitosanFerric Compoundsferric oxideGoldHorseradish PeroxidaseMagnetite NanoparticlesSarcosineSarcosine Oxidasebiomarkerbiosensorgold nanoparticlespersonalized medicinesuperparamagnetic iron oxide nanoparticlesTrinder reaction

Identifiers

PMID30467297
PMCPMC6320840
OpenAlexW2900895007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.