Evidence map›Paper›PMID 30467296›Full record

ArticleInternational journal of molecular sciences2018

Complementary Quantitative Structure⁻Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones.

Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Mauro S Nogueira, Gustavo H G Trossini, Thomas J Schmidt

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Natural Sesquiterpene Lactones of the 4,15-Molecules (Basel, Switzerland) · 2019
    Article
  6. Article
  7. Antitrypanosomal Activity of Sesquiterpene Lactones fromMolecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Njogu M KimaniInstitute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Muenster, PharmaCampus Corrensstrasse 48, D-48149 Muenster, Germany. m_kima01@uni-muenster.de.ORCID 0000-0002-5171-1940
Josphat C MatasyohDepartment of Chemistry, Egerton University, P.O. Box 536, Egerton 20115, Kenya. josphat2001@yahoo.com.
Marcel KaiserSwiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, CH-4051 Basel, Switzerland. marcel.kaiser@unibas.ch.
Mauro S NogueiraInstitute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Muenster, PharmaCampus Corrensstrasse 48, D-48149 Muenster, Germany. mauro.nogueira@tu-dortmund.de.
Gustavo H G TrossiniFaculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Lineu Prestes 580, 05508-000 São Paulo, Brazil. trossini@usp.br.
Thomas J SchmidtInstitute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Muenster, PharmaCampus Corrensstrasse 48, D-48149 Muenster, Germany. thomschm@uni-muenster.de.ORCID 0000-0003-2634-9705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three complementary quantitative structure⁻activity relationship (QSAR) methodologies, namely, regression modeling based on (i) "classical" molecular descriptors, (ii) 3D pharmacophore features, and (iii) 2D molecular holograms (HQSAR) were employed on the antitrypanosomal activity of sesquiterpene lactones (STLs) toward

Indexed as

Biological ProductsHydrophobic and Hydrophilic InteractionsInhibitory Concentration 50LactonesModels, MolecularMolecular StructurePlant ExtractsQuantitative Structure-Activity RelationshipSesquiterpenesTrypanocidal AgentsTrypanosoma brucei rhodesienseBiological ProductsLactonesPlant ExtractsSesquiterpenesTrypanocidal Agentshuman African trypanosomiasispharmacophore-based drug designQSARsesquiterpene lactonesTrypanosoma brucei

Identifiers

PMID30467296
PMCPMC6321053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.