Evidence map›Paper›PMID 30467287›Full record

ArticleMolecules (Basel, Switzerland)2018

On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition.

Luca Dellafiora, Gianni Galaverna, Gabriele Cruciani, Chiara Dall'Asta, Renato Bruni

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

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  13. Computational Approaches for Drug Discovery.Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luca DellafioraDepartment of Food and Drug, University of Parma, Area Parco delle Scienze 27/A, 43124 Parma, Italy. luca.dellafiora@unipr.it.ORCID 0000-0002-1901-3317
Gianni GalavernaDepartment of Food and Drug, University of Parma, Area Parco delle Scienze 27/A, 43124 Parma, Italy. gianni.galaverna@unipr.it.ORCID 0000-0001-9042-2378
Gabriele CrucianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, via Elce di Sotto, 8, 06123 Perugia, Italy. gabri@chemiome.chm.unipg.it.
Chiara Dall'AstaDepartment of Food and Drug, University of Parma, Area Parco delle Scienze 27/A, 43124 Parma, Italy. chiara.dallasta@unipr.it.
Renato BruniDepartment of Food and Drug, University of Parma, Area Parco delle Scienze 27/A, 43124 Parma, Italy. renato.bruni@unipr.it.ORCID 0000-0002-5992-8722
University of Parma · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

St. John's Wort (

Indexed as

Adenosine TriphosphateAnimalsAnthracenesAnti-Inflammatory AgentsBinding, CompetitiveComputer SimulationHypericumJanus Kinase 1Janus Kinase InhibitorsModels, MolecularMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructurePerylenePlant ExtractsAdenosine TriphosphateAnthracenesAnti-Inflammatory AgentshypericinJAK1 protein, humanJanus Kinase 1Janus Kinase InhibitorsPerylenePlant Extractsanti-inflammatory activityhypericinhypericin metabolitesHypericum perforatumin silico pharmacodynamicsjanus kinase 1

Identifiers

PMID30467287
PMCPMC6321526
OpenAlexW2900905258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.