ArticleMolecules (Basel, Switzerland)2018
Modular Synthesis and Biological Investigation of 5-Hydroxymethyl Dibenzyl Butyrolactones and Related Lignans.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents.RSC medicinal chemistry · 2024Article
- Synthesis and Anti-Proliferative Evaluation of Arctigenin Analogues with C-9' Derivatisation.International journal of molecular sciences · 2023Article
- Lignans.Molecules (Basel, Switzerland) · 2019Article
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8 authors.
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Abstract
Dibenzyl butyrolactone lignans are well known for their excellent biological properties, particularly for their notable anti-proliferative activities. Herein we report a novel, efficient, convergent synthesis of dibenzyl butyrolactone lignans utilizing the acyl-Claisen rearrangement to stereoselectively prepare a key intermediate. The reported synthetic route enables the modification of these lignans to give rise to 5-hydroxymethyl derivatives of these lignans. The biological activities of these analogues were assessed, with derivatives showing an excellent cytotoxic profile which resulted in programmed cell death of Jurkat T-leukemia cells with less than 2% of the incubated cells entering a necrotic cell death pathway.
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