ReviewPharmaceuticals (Basel, Switzerland)2018
Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia.
Review in Pharmaceuticals (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Oral iron-induced stunting is associated with increased Christensenella abundance in a piglet model for human infants.European journal of nutrition · 2026Article
- Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage.Animal genetics · 2026Article
- Effects of a second iron injection and sire line on growth performance, hemoglobin levels, antioxidative status, and whole-body iron retention in piglets.Journal of animal science · 2026Article
- Neonatal Blood Count Data of Piglets in Modern and Traditional Breeds following Spontaneous or Hormonally Induced Parturition.International journal of veterinary science and medicine · 2026Article
- Dietary ferrous glycinate supplementation reshapes the gut microbiota and improves intestinal barrier function in weaned piglets by reducing luminal iron accumulation.Frontiers in veterinary science · 2026Article
- Infantile Anemia and Iron Treatments Affect the Gut Microbiome of Young Rhesus Monkeys.Microorganisms · 2025Article
- Effect of second iron injection on growth performance, hematological parameters, and fecal microbiome of piglets fed different dietary iron levels.Journal of animal science · 2025Article
- Dietary Fe-Gly supplementation attenuates enterotoxigenicFrontiers in veterinary science · 2025Article
- Intramuscular iron supplementation enhances intestinal barrier function in weaned piglets challenged with enterotoxigenicFrontiers in cellular and infection microbiology · 2025Article
- Effects of dietary inorganic and organic iron sources on maternal and piglet iron status across one complete reproductive cycle in highly prolific sows.Translational animal science · 2025Article
- Feeding a nutrient enriched diet to late gestating sows across consecutive cycles improves micronutrient status, farrowing duration, and prolificacy.Translational animal science · 2025Article
- Comparison of Molecular Potential for Iron Transfer across the Placenta in Domestic Pigs with Varied Litter Sizes and Wild Boars.International journal of molecular sciences · 2024Article
- Iron status in piglets at three days of age and at weaning and possible seasonal effects on the blood haemoglobin levels in a Swedish outdoor pig-producing farm.Acta veterinaria Scandinavica · 2024Article
- Impact of litter size on the hematological and iron status of gilts, sows and newborn piglets: a comparative study of domestic pigs and wild boars.BMC veterinary research · 2024Article
- Vitality in Newborn Farm Animals: Adverse Factors, Physiological Responses, Pharmacological Therapies, and Physical Methods to Increase Neonate Vigor.Animals : an open access journal from MDPI · 2023Review
- Effects of Different Iron Supplements on Reproductive Performance and Antioxidant Capacity of Pregnant Sows as Well as Iron Content and Antioxidant Gene Expression in Newborn Piglets.Animals : an open access journal from MDPI · 2023Article
- Comparison of efficacy of needle-free injection versus injection by needle for iron supplementation of piglets: a double blind randomized controlled trial.Porcine health management · 2023Article
- H-ferritin in sows' colostrum- and milk-derived extracellular vesicles: a novel iron delivery concept.Journal of animal science · 2023Article
- Effects of dietary iron sources on growth performance, iron status, Fe-containing enzyme activity and gene expression related to iron homeostasis in tissues of weaned pigs.Frontiers in veterinary science · 2023Article
- Effect of Additional Iron Injection to Suckling Pigs on Hematocrit Level during the Suckling Period.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period, frequently developing into a serious illness. On the other hand, in humans, only low-birth-weight infants, including premature infants, are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter sizes and high birth weights. As a consequence, pregnant sows cannot provide a sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of a large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.