Evidence map›Paper›PMID 30467237›Full record

ArticleEMBO reports2019

The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.

Borhan Uddin, Patrick Partscht, Nan-Peng Chen, Annett Neuner, Manuel Weiß, Robert Hardt, Aliakbar Jafarpour, Bernd Heßling, Thomas Ruppert, Holger Lorenz and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  10. Novel compound heterozygous variants in theFrontiers in pediatrics · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. PIPCommunications biology · 2022
    Article
  17. TRIP6 functions in brain ciliogenesis.Nature communications · 2021
    Article
  18. Article
  19. Moonlighting of mitotic regulators in cilium disassembly.Cellular and molecular life sciences : CMLS · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Borhan UddinDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.ORCID 0000-0001-9142-7568
Patrick PartschtDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Nan-Peng ChenDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Annett NeunerDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Manuel WeißDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Robert HardtDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Aliakbar JafarpourDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.ORCID 0000-0002-1460-5743
Bernd HeßlingDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Thomas RuppertDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Holger LorenzDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
Gislene PereiraDKFZ-ZMBH Alliance and Molecular Biology of Centrosomes and Cilia Unit, Centre for Organismal Studies and German Cancer Research Center, Heidelberg, Germany gislene.pereira@cos.uni-heidelberg.de e.schiebel@zmbh.uni-heidelberg.de.ORCID 0000-0002-6519-4737
Elmar SchiebelDKFZ-ZMBH Allianz, Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany gislene.pereira@cos.uni-heidelberg.de e.schiebel@zmbh.uni-heidelberg.de.ORCID 0000-0002-3683-247X
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CDC14A codes for a conserved proline-directed phosphatase, and mutations in the gene are associated with autosomal-recessive severe to profound deafness, due to defective kinocilia. A role of CDC14A in cilia formation has also been described in other organisms. However, how human CDC14A impacts on cilia formation remains unclear. Here, we show that human RPE1 hCDC14A

Indexed as

Actin-Related Protein 2ActinsCell LineCell MovementCentrosomeCiliaCyclin-Dependent Kinase 5EndocytosisGene Expression Regulation, DevelopmentalHumansMicrotubulesMutationMyosin Heavy ChainsMyosin Type VNeuropeptidesPhosphoric Monoester HydrolasesActin-Related Protein 2ActinsACTR2 protein, humanCDC14A protein, humanCDK5 protein, humanCyclin-Dependent Kinase 5drebrinsMYO5A protein, humanMyosin Heavy ChainsMyosin Type VNeuropeptidesPhosphoric Monoester HydrolasesProtein Tyrosine PhosphatasesProteomeactinCDK5DBN1hCDC14Aprimary cilium

Identifiers

PMID30467237
PMCPMC6322383
OpenAlexW2901915356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.