ArticleAJNR. American journal of neuroradiology2019
Cesarean Delivery Impacts Infant Brain Development.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pediatrics Consequences of Caesarean Section-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- Birth-related characteristics predict vision-related quality of life in adults: A population-based study.PloS one · 2026Article
- Temporal Changes in Brain Light Scattering and Its Independent Variables Within 2 Days of Life.Biosensors · 2025Article
- Harnessing the microbiota-gut-brain axis to prevent and treat pediatric neurodevelopmental disorders: translational insights and strategies.Journal of translational medicine · 2025Review
- Review
- Can Vaginal Seeding at Birth Improve Health Outcomes of Cesarean Section-Delivered Infants? A Scoping Review.Microorganisms · 2025Review
- Cesarean delivery on child health and development in Japanese nationwide birth cohort.Scientific reports · 2025Article
- Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.Scientific reports · 2024Article
- Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally.Scientific reports · 2023Article
- Maternal and neonatal blood vitamin D status and neurodevelopment at 24 months of age: a prospective birth cohort study.World journal of pediatrics : WJP · 2023Article
- Association between Cesarean section and neurodevelopmental disorders in a Japanese birth cohort: the Japan Environment and Children's Study.BMC pediatrics · 2023Article
- Neuroanatomical and functional consequences of oxytocin treatment at birth in prairie voles.Psychoneuroendocrinology · 2023Article
- C-section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying Lachnoclostridium [clostridium] scindens in mice.Physiological reports · 2022Article
- Mode of Neonatal Delivery Influences the Nutrient Composition of Human Milk: Results From a Multicenter European Cohort of Lactating Women.Frontiers in nutrition · 2022Article
- Delivery Mode and Child Development at 20 Months of Age and 7 Years of Age in the Republic of Seychelles.Maternal and child health journal · 2021Article
- Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China.European journal of pediatrics · 2021Article
- Sex differences in associations between birth characteristics and childhood cancers: a five-state registry-linkage study.Cancer causes & control : CCC · 2021Article
- Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19.Neuroscience and biobehavioral reviews · 2021Review
- Are there adverse outcomes for child health and development following caesarean section delivery? Can we justify using elective caesarean section to prevent obstetric pelvic floor damage?International urogynecology journal · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
background and purposeThe cesarean delivery rate has increased globally in the past few decades. Neurodevelopmental outcomes associated with cesarean delivery are still unclear. This study investigated whether cesarean delivery has any effect on the brain development of offspring. MATERIALS AND
methodsA total of 306 healthy children were studied retrospectively. We included 3 cohorts: 2-week-old neonates (cohort 1,
resultsWhile not all MR imaging techniques were shared across the institutions/cohorts, post hoc analyses showed similar results of potential effects of cesarean delivery. The cesarean delivery group in cohort 1 showed significantly lower white matter development in widespread brain regions and significantly lower functional connectivity in the brain default mode network, controlled for a number of potential confounders. No group differences were found in cohort 2 in white matter integrity or gray matter volume. Cohort 3 had significantly different trajectories of white matter myelination between groups, with those born by cesarean delivery having reduced myelin in infancy but normalizing with age.
conclusionsCesarean delivery may influence infant brain development. The impact may be transient because similar effects were not observed in older children. Further prospective and longitudinal studies may be needed to confirm these novel findings.
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