Evidence map›Paper›PMID 30467217›Full record

ArticleAJNR. American journal of neuroradiology2018

Retrospective Review of Otic Capsule Contour and Thickness in Patients with Otosclerosis and Individuals with Normal Hearing on CT.

N Sanghan, T Chansakul, E D Kozin, A F Juliano, H D Curtin, K L Reinshagen

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Current trends in imaging for otosclerosis and the potential role of photon-counting computed tomography.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Review
  4. Artificial Intelligence for Otosclerosis Detection: A Pilot Study.Journal of imaging informatics in medicine · 2024
    Article
  5. Article
  6. Article
  7. Imaging Studies in Otosclerosis: An Up-to-date Comprehensive Review.International archives of otorhinolaryngology · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

N SanghanFrom the Department of Radiology (N.S.), Prince of Songkla University, Hadyai, Songkhla, Thailand.ORCID 0000-0002-3814-4988
T ChansakulFrom the Department of Radiology (N.S.), Prince of Songkla University, Hadyai, Songkhla, Thailand.ORCID 0000-0002-8304-226X
E D KozinFrom the Department of Radiology (N.S.), Prince of Songkla University, Hadyai, Songkhla, Thailand.ORCID 0000-0002-0305-0682
A F JulianoFrom the Department of Radiology (N.S.), Prince of Songkla University, Hadyai, Songkhla, Thailand.ORCID 0000-0002-5088-5367
H D CurtinFrom the Department of Radiology (N.S.), Prince of Songkla University, Hadyai, Songkhla, Thailand.ORCID 0000-0003-2163-9404
K L ReinshagenFrom the Department of Radiology (N.S.), Prince of Songkla University, Hadyai, Songkhla, Thailand katherine_reinshagen@meei.harvard.edu.ORCID 0000-0003-3705-1082

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
NCATS NIH HHS UL1 TR002541
6 · The paper itself

Abstract

background and purposeOtosclerosis is commonly identified on CT as a focus of hypodensity in the otic capsule anterior to the oval window. However, otosclerosis can have a sclerotic phase approximating the density of normal bone, making diagnosis challenging. This study assesses differences in otic capsule contour and thickness anterolateral to the anterior margin of the oval window in patients with otosclerosis compared with individuals with normal hearing. MATERIALS AND

methodsAxial CT of 104 ears with clinically diagnosed otosclerosis and 108 consecutive ears of audiometrically normal individuals were retrospectively reviewed. Two radiologists independently evaluated the pattern of otosclerosis, otic capsule contour, and bone thickness on standardized axial images at the level of the oval window and cochleariform process. Measurements were made from the posterolateral margin of the cochlea to the apex of the otic capsule convex contour just anterolateral to the anterior margin of the oval window. In the absence of a convex contour, the sulcus between the oval window and the cochleariform process was identified, and measurement to the depth of the sulcus was used. Receiver operating characteristic analysis determined the best cutoff value of otic capsule thickness.

resultsMean otic capsule thickness (2 SDs) was 3.08 (0.93) mm and 1.82 (0.31) mm in patients with otosclerosis and individuals with normal hearing, respectively (

conclusionsPatients with otosclerosis have significantly thicker bone abutting the oval window than individuals with normal hearing.

Indexed as

AdultAgedEar, InnerFemaleHumansMaleMiddle AgedOtosclerosisRetrospective StudiesTomography, X-Ray Computed

Identifiers

PMID30467217
PMCPMC6295232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.