Evidence map›Paper›PMID 30467204›Full record

ArticleHaematologica2019

Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia.

Tadbir K Bariana, Veerle Labarque, Jessica Heremans, Chantal Thys, Mara De Reys, Daniel Greene, Benjamin Jenkins, Luigi Grassi, Denis Seyres, Frances Burden and 12 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Local genetic correlation analysis of Alzheimer's disease and stroke implicatesmedRxiv : the preprint server for health sciences · 2025
    Article
  6. Production of plateletsHaematologica · 2025
    Article
  7. Review
  8. Human genetic defects of sphingolipid synthesis.Journal of inherited metabolic disease · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Tadbir K BarianaDepartment of Haematology, University College London, UK.
Veerle LabarqueDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
Jessica HeremansDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
Chantal ThysNIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
Mara De ReysDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium.
Daniel GreeneDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Benjamin JenkinsNIHR Biomedical Research Centre Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge Biomedical Campus, UK.
Luigi GrassiDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Denis SeyresDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Frances BurdenDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Deborah WhitehornDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Olga ShamardinaDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Sofia PapadiaDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Keith GomezDepartment of Haematology, University College London, UK.
Nihr BioResourceNIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
Chris Van GeetNIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.
Albert KoulmanNIHR Biomedical Research Centre Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge Biomedical Campus, UK.
Willem H OuwehandDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Cedric GhevaertDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Mattia FrontiniDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Ernest TurroDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.
Kathleen FresonNIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK kathleen.freson@med.kuleuven.be.
University of Cambridge · GBKU Leuven · BEBritish Heart Foundation · GBMRC Biostatistics Unit · GBNHS Blood and Transplant · GBRoyal Free London NHS Foundation Trust · GBUniversity College London · GB

Funding

British Heart Foundation FS/18/53/33863Medical Research Council MC_PC_12009Medical Research Council MC_UU_12012/5
6 · The paper itself

Abstract

Sphingolipids are fundamental to membrane trafficking, apoptosis, and cell differentiation and proliferation. KDSR or 3-keto-dihydrosphingosine reductase is an essential enzyme for

Indexed as

Alcohol OxidoreductasesAnimalsBlood PlateletsCell DifferentiationCells, CulturedChildFemaleHumansInduced Pluripotent Stem CellsMaleMegakaryocytesMetabolomicsMutationPedigreePrognosisSphingolipids3-ketodihydrosphingosine reductaseAlcohol OxidoreductasesSphingolipids

Identifiers

PMID30467204
PMCPMC6518879
OpenAlexW2900467511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.