Evidence map›Paper›PMID 30466757›Full record

ReviewBest practice & research. Clinical haematology2018

Hematopoietic cell transplantation as treatment of patients with acute myeloid leukemia with measurable residual disease after consolidation therapy.

Frederick R Appelbaum

Abstract readReview
In one paragraph

Review in Best practice & research. Clinical haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Measurable Residual Disease.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Use of Minimal Residual Disease in Acute Myeloid Leukemia Therapy.Current treatment options in oncology · 2020
    Review
  3. Minimal residual disease and stem cell transplantation outcomes.Hematology. American Society of Hematology. Education Program · 2019
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Frederick R AppelbaumFred Hutchinson Cancer Research Center and University of Washington, 100 Fairview Avenue N, D5-310, Seattle, WA 98109, USA. Electronic address: fappelba@fredhutch.org.
University of Washington · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Geoffrey Roger HILL · 1985 to 2026
$128.4M
NCI NIH HHS P01 CA018029NCI NIH HHS P30 CA015704
6 · The paper itself

Abstract

The persistence of measurable residual disease (MRD) following induction chemotherapy is the single most powerful prognostic factor available to clinicians treating patients with acute myeloid leukemia (AML). How to use this information to guide subsequent therapy is complex, and influenced by the category of AML being treated, the assays used to measure MRD, MRD levels and kinetics, and the spectrum of therapies available to the patient. In this literature-based review, each of these issues will be discussed, with a particular emphasis on the role of hematopoietic cell transplantation in the treatment of MRD-positive patients.

Indexed as

Hematopoietic Stem Cell TransplantationAllograftsConsolidation ChemotherapyHumansInduction ChemotherapyLeukemia, Myeloid, AcuteNeoplasm, ResidualNucleophosminNucleophosminAcute myeloid leukemiaAMLCore binding factorHCTHematopoietic cell transplantationMeasurable residual diseaseMFCMRDMulti-parameter flow cytometryNext generation sequencingNGSNPM1Reverse transcriptase polymerase chain reactionRT-PCR

Identifiers

PMID30466757
PMCPMC6347460
OpenAlexW2890914798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.