ArticleCritical care (London, England)2018
Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.
Article in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 229 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Health-related Quality of Life (HRQOL) and Physical Performance in Individuals After COVID-19 Induced Hospitalisation and the Impact of a Standard Care Follow-up Program: a Longitudinal Observational Cohort Study
Development and Evaluation of a Nursing Intervention in the Patient Being Discharged From the Intensive Care Unit: a Protocol for Mixed Methods Research
Who cites it
229 citing papers in PubMed, 7 syntheses or guidelines pooled it, 531 citations in OpenAlex.
- Pooled it
- Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model.Intensive care medicine · 2024Pooled it
- Guideline on multimodal rehabilitation for patients with post-intensive care syndrome.Critical care (London, England) · 2023Guideline
- Pooled it
- Psychiatric symptoms in Long-COVID patients: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Development of the support needs after ICU (SNAC) questionnaire.Nursing in critical care · 2022Pooled it
- The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis.Annals of the New York Academy of Sciences · 2021Pooled it
- Effects of a brief primary care intervention for post-traumatic stress disorder symptoms after critical illness on health-related quality of life - A secondary analysis of the PICTURE randomised controlled trial.The European journal of general practice · 2026Trial
- Depressive symptoms are a key determinant of health-related quality of life in ICU survivors with psychological distress.Scientific reports · 2026Trial
- Online narrative therapy intervention improves post-traumatic stress disorder symptoms, perceived stress, anxiety, and depression in nurses: a randomized controlled trial.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Trial
- A randomized clinical trial to evaluate the effect of post-intensive care multidisciplinary consultations on mortality and the quality of life at 1 year.Intensive care medicine · 2024Trial
- Effects of the Healing Beats Program among University Students after Exposure to a Source of Psychological Stress: A Randomized Control Trial.International journal of environmental research and public health · 2021Trial
- The emotional impact of the COVID-19 pandemic on individuals with progressive multiple sclerosis.Journal of neurology · 2021Trial
- Acute Respiratory Failure Survivors' Perspectives on Patient-Centered Communication: A Mixed Methods Study.Critical care explorations · 2026Observational
- Post-traumatic stress disorder following intensive care for COVID-19: a single-center retrospective follow-up study.BMC anesthesiology · 2026Article
- Effects of expiratory muscle strength training on swallowing in survivors of critical illness: A systematic review and narrative synthesis.Journal of the Intensive Care Society · 2026Article
- Determinants of caregiver burden among family caregivers of post-intensive care syndrome patients at 2 weeks post-discharge: a cross-sectional study.BMC nursing · 2026Article
- Early Sedation Intensity and Psychological Outcomes in Critically Ill Adults.Nursing in critical care · 2026Article
- [Ethically challenging determination of treatment goals in the intensive care unit: reasons, frequency and possible solutions].Die Anaesthesiologie · 2026Review
- Physical, psychological, and cognitive function and quality of life in survivors of severe critical illness.Scientific reports · 2026Article
169 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stress disorder (PTSD) caseness in the first year following discharge from an intensive care unit (ICU).
methodsDesign: prospective multicentre follow-up study of survivors of ICU in the UK.
settingpatients from 26 ICUs in the UK. INCLUSION CRITERIA: patients who had received at least 24 h of level 3 ICU care and were 16 years of age or older.
interventionspostal follow up: Hospital Anxiety and Depression Score (HADS) and the Post-Traumatic Stress Disorder (PTSD) Check List-Civilian (PCL-C) at 3 and 12 months following discharge from ICU.
main outcome measurecaseness of anxiety, depression and PTSD, 2-year survival.
resultsIn total, 21,633 patients admitted to ICU were included in the study. Postal questionnaires were sent to 13,155 survivors; of these 38% (4943/13155) responded and 55% (2731/4943) of respondents passed thresholds for one or more condition at 3 or 12 months following discharge. Caseness prevalence was 46%, 40% and 22% for anxiety, depression and PTSD respectively; 18% (870/4943 patients) met the caseness threshold for all three psychological conditions. Patients with symptoms of depression were 47% more likely to die during the first 2 years after discharge from ICU than those without (HR 1.47, CI 1.19-1.80).
conclusionsOver half of those who respond to postal questionnaire following treatment on ICU in the UK reported significant symptoms of anxiety, depression or PTSD. When symptoms of one psychological disorder are present, there is a 65% chance they will co-occur with symptoms of one of the other two disorders. Depression following critical illness is associated with an increased mortality risk in the first 2 years following discharge from ICU.
trial registrationISRCTN Registry, ISRCTN69112866 . Registered on 2 May 2006.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.