Evidence map›Paper›PMID 30466476›Full record

ReviewJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2018

Marijuana and head and neck cancer: an epidemiological review.

Michael Xie, Michael K Gupta, Stuart D Archibald, B Stanley Jackson, James Edward Massey Young, Han Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Cannabis related side effects in otolaryngology: a scoping review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael XieDivision of Otolaryngology-Head and Neck Surgery, McMaster University, G811, 50 Charlton Avenue E, Hamilton, ON, L8N 4A6, Canada.
Michael K GuptaDivision of Otolaryngology-Head and Neck Surgery, McMaster University, G811, 50 Charlton Avenue E, Hamilton, ON, L8N 4A6, Canada.
Stuart D ArchibaldMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
B Stanley JacksonDivision of Otolaryngology-Head and Neck Surgery, McMaster University, G811, 50 Charlton Avenue E, Hamilton, ON, L8N 4A6, Canada.
James Edward Massey YoungDivision of Otolaryngology-Head and Neck Surgery, McMaster University, G811, 50 Charlton Avenue E, Hamilton, ON, L8N 4A6, Canada.
Han ZhangDivision of Otolaryngology-Head and Neck Surgery, McMaster University, G811, 50 Charlton Avenue E, Hamilton, ON, L8N 4A6, Canada. hanzhang@stjosham.on.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMarijuana is the most widely used illicit substance in Canada. To date, no conclusive study has looked at the epidemiologic basis of marijuana use and head and neck cancer (HNC). Due to the imminent recreational legalization of marijuana in Canada, the epidemiologic relationship between marijuana use and HNC is becoming increasingly important.

objectiveTo examine the epidemiologic characteristics of HNC patients who are recreational marijuana users.

methodsThis study was conducted at a single tertiary care centre from 2011 to 2014. Patients were enrolled consecutively at time of diagnosis of malignancy. Data was prospectively collected and included socioeconomic factors, alcohol/tobacco history, tumor characteristics, and treatment modality. Marijuana use was defined as current usage on an at least weekly basis.

resultsEight hundred seventy-nine patients met inclusion and exclusion criteria. Seventy-four (8.4%) patients were classified as marijuana users. Compared to non-users, marijuana users were less likely to be married (p = 0.048) and had less significant tobacco smoking history (p = 0.004). There were no significant differences between other socioeconomic factors or local and regional disease (p > 0.05). Marijuana users differed in the proportion of cancers stratified by primary site (p < 0.0001), with higher rates of p16+ oropharyngeal cancers, and treatment modality (p < 0.0001), with more use of chemoradiation.

conclusionsHNC patients who were marijuana users were less likely to be married and smoke tobacco. They have a distinct cancer site prevalence and are more likely to be treated by chemoradiation. Understanding the epidemiological breakdown of marijuana users amongst HNC patients will be a useful adjunct for future studies.

Indexed as

Head and Neck NeoplasmsAdolescentAdultCanadaCannabisChemoradiotherapyFemaleHumansMaleMarijuana SmokingMarital StatusMiddle AgedOropharyngeal NeoplasmsSocioeconomic FactorsTobacco SmokingCancer epidemiologyHead and neck cancerMarijuana

Identifiers

PMID30466476
PMCPMC6249858

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.