Evidence map›Paper›PMID 30466433›Full record

ArticleRespiratory research2018

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema.

Feng Li, Mengmeng Xu, Muyun Wang, Lei Wang, Hanying Wang, Hai Zhang, Yuqing Chen, Jicheng Gong, Junfeng Jim Zhang, Ian M Adcock and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 113 citations in OpenAlex.

  1. Review
  2. Review
  3. Air pollution-induced airway epithelial barrier dysfunction in COPD: a narrative review of mechanisms and therapeutic implications.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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  7. CD207-Positive Dendritic Cells Promote Emphysema Through CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Feng LiDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, People's Republic of China.
Mengmeng XuDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, People's Republic of China.
Muyun WangDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, People's Republic of China.
Lei WangDepartment of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, No.100, Haining Road, Shanghai, 200080, China.
Hanying WangDepartment of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, No.100, Haining Road, Shanghai, 200080, China.
Hai ZhangDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, People's Republic of China.
Yuqing ChenDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, People's Republic of China.
Jicheng GongDuke Global Health Institute and Nicholas School of the Environment, Duke University, Durham, NC, 27708, USA.
Junfeng Jim ZhangDuke Global Health Institute and Nicholas School of the Environment, Duke University, Durham, NC, 27708, USA.
Ian M AdcockAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.
Kian Fan ChungAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.
Xin ZhouDepartment of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, No.100, Haining Road, Shanghai, 200080, China. xzhou53@163.com.
Shanghai Chest Hospital · CNShanghai First People's Hospital · CNDuke University · USImperial College London · GB

Funding

Project of National Nature Science Foundation of China No.81470218Shanghai Pujiang Program No.14PJD027the Key International (Regional) Cooperative Project of National Natural Science Foundation of China No.51420105010
6 · The paper itself

Abstract

backgroundMitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) and other stimuli. We examined the importance of mtROS and NLRP3 inflammasome and their interactions in multiple ozone-induced lung inflammation and emphysema.

methodsC57/BL6 mice were exposed to ozone (2.5 ppm, 3 h) or filtered air twice a week over 6 weeks. MitoTEMPO (20 mg/kg), an inhibitor of mtROS, and VX765 (100 mg/kg), an inhibitor of caspase-1 activity, were administered by intraperitoneal or intragastric injection respectively 1 h prior to each ozone exposure for 6 weeks.

resultsOzone-exposed mice had increased bronchoalveolar lavage (BAL) total cells and levels of IL-1β, KC and IL-6, augmented lung tissue inflammation scores, enhanced oxidative stress with higher serum 8-OHdG concentrations, emphysema with greater mean linear intercept (Lm), airway remodeling with increased airway smooth muscle mass and airflow limitation as indicated by a reduction in the ratio of forced expiratory volume at 25 and 50 milliseconds to forced vital capacity (FEV

conclusionsBoth mtROS and NLRP3 inflammasome play a role in ozone-induced lung inflammation while only NLRP3 is involved in ozone-induced emphysema.

Indexed as

AnimalsEmphysemaMaleMiceMice, Inbred C57BLMitochondriaNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressOzonePneumoniaReactive Oxygen SpeciesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOzoneReactive Oxygen SpeciesEmphysemaLung inflammationMitochondrial ROSNLRP3 inflammasomeOzone

Identifiers

PMID30466433
PMCPMC6249848
OpenAlexW2900485382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.