ArticleBMC cancer2018
Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 8 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 8 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Global quality of life and mortality risk in patients with cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Association between quality of life and mortality risk in patients with breast cancer: a systematic review and meta-analysis.Breast cancer (Tokyo, Japan) · 2024Pooled it
- Baseline functioning scales of EORTC QLQ-C30 predict overall survival in patients with gastrointestinal cancer: a meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Systematic Review of Cognitive Impairment in Colorectal Cancer Survivors Who Received Chemotherapy.Oncology nursing forum · 2021Pooled it
- Pooled it
- Probiotic/Synbiotic Treatment and Postoperative Complications in Colorectal Cancer Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials.Clinical and translational gastroenterology · 2020Pooled it
- The use of survivorship care plans by female racial and ethnic minority breast cancer survivors: a systematic review.Journal of cancer survivorship : research and practice · 2020Pooled it
- Physical activity interventions for disease-related physical and mental health during and following treatment in people with non-advanced colorectal cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Trial
- Machine learning-based random forest for predicting decreased quality of life in thyroid cancer patients after thyroidectomy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Health-related quality of life trajectories in older adult long-term survivors of colorectal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Health-related quality of life is a significant prognostic factor for recurrence and overall survival in patients with colon cancer.BMC cancer · 2025Observational
- Quality of life outcomes in colorectal cancer survivors: insights from an observational study at a tertiary cancer center.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Observational
- The quality of life of colorectal cancer patients attending the cancer center in addis Ababa, Ethiopia.BMC cancer · 2025Article
- Assessing the performance of QLQ-C30 in predicting all-cause mortality in community cancer patients.BMC cancer · 2025Article
- Factors influencing the quality of life in survivors of differentiated thyroid cancer based on patient-reported outcomes: a single-center cross-sectional study.Frontiers in endocrinology · 2025Article
- Impact of Multimorbidity Burden on Mortality Risk among Colon Cancer Survivors.Journal of Cancer · 2025Article
- Using a modified Delphi procedure to select a PRO-CTCAE-based subset for patient-reported symptomatic toxicity monitoring in rectal cancer patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- A comprehensive evaluation of 80 consecutive robotic low anterior resections: impact of not mobilizing the splenic flexure alongside low-tie vascular ligation as a standardized technique.Journal of robotic surgery · 2024Observational
- Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe group of colorectal cancer (CRC) survivors continues to grow worldwide. Understanding health-related quality of life (HRQOL) determinants and consequences of HRQOL impairments in long-term CRC survivors may help to individualize survivorship care plans. We aimed to i) examine the HRQOL status of CRC long-term survivors, ii) identify cross-sectional sociodemographic and clinical correlates of HRQOL, and iii) investigate the prospective association of HRQOL after CRC diagnosis with all-cause mortality.
methodsWe assessed HRQOL within a Northern German cohort of 1294 CRC survivors at a median of 6 years after CRC diagnosis using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Cross-sectional correlates of different HRQOL dimensions were analyzed using multivariable-adjusted logistic regression models with HRQOL as a binary variable. With multivariable-adjusted Cox proportional hazards regression models, hazard ratios (HR) of all-cause mortality were estimated per 10-point-increments of an HRQOL summary score, a global quality of life scale, and HRQOL functioning and symptom domains.
resultsThe median HRQOL summary score was 87 (interquartile range: 75-94). Sex, age, education, tumor location, metastases, other cancers, type of therapy, and current stoma were identified as correlates of different HRQOL scales. After a median follow-up time of 7 years after HRQOL assessment, 175 participants had died. Nearly all HRQOL domains, except for cognitive functioning and diarrhea, were significantly associated with all-cause mortality. A 10-point-increment in the summary score decreased the risk of death by 24% (HR: 0.76; 95% CI: 0.70-0.82).
conclusionsHRQOL in CRC survivors appeared to be relatively high in the long term. Various clinical and sociodemographic factors were cross-sectionally associated with HRQOL in long-term CRC survivors. Lower HRQOL was associated with increased all-cause mortality. Individualized healthcare programs for CRC survivors (including psychosocial screening and interventions) are needed to detect decreased HRQOL and to further improve long-term HRQOL and survival.
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