Evidence map›Paper›PMID 30466304›Full record

ArticleAIDS care2019

Predictors of postpartum HIV care engagement for women enrolled in prevention of mother-to-child transmission (PMTCT) programs in Tanzania.

Melissa H Watt, Cody Cichowitz, Godfrey Kisigo, Linda Minja, Brandon A Knettel, Elizabeth T Knippler, James Ngocho, Preeti Manavalan, Blandina T Mmbaga

Abstract read
In one paragraph

Article in AIDS care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa H Watta Duke Global Health Institute , Duke University , Durham , NC , USA.
Cody Cichowitza Duke Global Health Institute , Duke University , Durham , NC , USA.
Godfrey Kisigoa Duke Global Health Institute , Duke University , Durham , NC , USA.
Linda Minjac Kilimanjaro Clinical Research Institute , Moshi , Tanzania.
Brandon A Knettela Duke Global Health Institute , Duke University , Durham , NC , USA.
Elizabeth T Knipplera Duke Global Health Institute , Duke University , Durham , NC , USA.
James Ngochod Kilimanjaro Christian Medical Centre , Moshi , Tanzania.
Preeti Manavalana Duke Global Health Institute , Duke University , Durham , NC , USA.
Blandina T Mmbagaa Duke Global Health Institute , Duke University , Durham , NC , USA.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
Sociobehavioral Sciences Research to Improve Care for HIV Infection in TanzaniaD43TW009595 · FIC · KILIMANJARO CHRISTIAN MEDICAL CENTRE · PI Blandina Theophil Mmbaga · 2013 to 2026
$4.2M
Strengthening of Research Capacity for Junior Faculty in TanzaniaD43TW010138 · FIC · KILIMANJARO CHRISTIAN MEDICAL COLLEGE · PI MTETA, ALFRED KIEN · 2015 to 2020
$3.2M
A stigma reduction intervention at time of entry into antenatal care to improve PMTCT services in TanzaniaR21TW011053 · FIC · UNIVERSITY OF UTAH · PI MMBAGA, BLANDINA THEOPHIL, WATT, MELISSA H · 2018 to 2019
$424k
Postpartum HIV care engagement in the context of Option B+ in TanzaniaR21AI124344 · NIAID · DUKE UNIVERSITY · PI MMBAGA, BLANDINA THEOPHIL, WATT, MELISSA H · 2016 to 2017
$314k
FIC NIH HHS D43 TW009595FIC NIH HHS D43 TW010138FIC NIH HHS R21 TW011053NIAID NIH HHS P30 AI064518NIAID NIH HHS R21 AI124344NIAID NIH HHS T32 AI007392
6 · The paper itself

Abstract

Prevention of mother-to-child transmission of HIV (PMTCT) is a foundational component of a comprehensive HIV treatment program. In addition to preventing vertical transmission to children, PMTCT is an important catch-point for universal test-and-treat strategies that can reduce community viral load and slow the epidemic. However, systematic reviews suggest that care engagement in PMTCT programs is sub-optimal. This study enrolled a cohort of 200 women initiating PMTCT in Kilimanjaro, Tanzania, and followed them to assess HIV care engagement and associated factors. Six months after delivery, 42/200 (21%) of participants were identified as having poor care engagement, defined as HIV RNA >200 copies/mL or, if viral load was unavailable, being lost-to-follow-up in the clinical records or self-reporting being out of care. In a multivariable risk factor analysis, younger women were more likely to have poor postpartum care engagement; with each year of age, women were 7% less likely to have poor care engagement (aRR: 0.93; 95% CI: 0.89, 0.98). Additionally, women who had told at least one person about their HIV status were 47% less likely to have poor care engagement (aRR: .53; 95% CI: 0.29, 0.97). Among women who entered antenatal care with an established HIV diagnosis, those who were pregnant for the first time had increased risk of poor care engagement (aRR 4.16; 95% CI 1.53, 11.28). The findings suggest that care engagement remains a concern in PMTCT programs, and must be addressed to realize the goals of PMTCT. Comprehensive counseling on HIV disclosure, along with community-based stigma reduction programs to provide a supportive environment for people living with HIV, are crucial to address barriers to care engagement and support long-term treatment. Women presenting to antenatal care with an established HIV status require support for care engagement during the crucial period surrounding childbirth, particularly those pregnant for the first time.

Indexed as

Social StigmaAdultAnti-Retroviral AgentsCohort StudiesContinuity of Patient CareCounselingFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalLost to Follow-UpMothersPatient Acceptance of Health CarePostpartum PeriodPregnancyPregnancy Complications, InfectiousAnti-Retroviral Agentscare engagementHIVpregnancyprevention of mother-to-child transmission of HIV (PMTCT)Tanzania

Identifiers

PMID30466304
PMCPMC6443456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.