Evidence map›Paper›PMID 30466188›Full record

ArticlePaediatric and perinatal epidemiology2018

The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers.

Gabriella Tikellis, Terence Dwyer, Ora Paltiel, Gary S Phillips, Stanley Lemeshow, Jean Golding, Kate Northstone, Andy Boyd, Sjurdur Olsen, Akram Ghantous and 22 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Gabriella TikellisPopulation Epidemiology, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-5154-6658
Terence DwyerPopulation Epidemiology, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Ora PaltielBraun School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Gary S PhillipsCenter for Biostatistics, Department of Biomedical Informatics, Ohio State University, Columbus, Ohio, USA.
Stanley LemeshowDivision of Biostatistics, College of Public Health, Ohio State University, Columbus, Ohio, USA.
Jean GoldingPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Kate NorthstonePopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Andy BoydPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Sjurdur OlsenCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Akram GhantousEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Zdenko HercegEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Jørn OlsenDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
Marin StrömCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Somdat MahabirDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Rena R JonesOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Anne-Louise PonsonbyPopulation Epidemiology, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Jacqueline ClavelCentre for Research in Epidemiology and Statistics, Institut National de la Santé et de la Recherche Médicale, Sorbonne Paris Cité, Villejuif, France.
Marie Aline CharlesCentre for Research in Epidemiology and Statistics, Institut National de la Santé et de la Recherche Médicale, Sorbonne Paris Cité, Villejuif, France.
Edwin TrevathanVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Zhengmin Min QianCollege for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri, USA.
Milena M MauleCancer Epidemiology Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
Xiu QiuDivision of the Birth Cohort Study, Department of Woman and Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-1248-229X
Yun-Chul HongInstitute of Environmental Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
Silvia BrandaliseBoldrini Children's Center, Campinas, Brazil.
Eve RomanEpidemiology and Cancer Statistics Group, Health Sciences, York University, York, UK.
Melissa WakePopulation Epidemiology, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Jian-Rong HeDivision of the Birth Cohort Study, Department of Woman and Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Martha S LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-1687-5587
International Childhood Cancer Cohort Consortium

Funding

Studies of Populations Exposed to Therapeutic Medical Radiation and Other AgentsZIACP010131 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MORTON, LINDSAY · 2009 to 2025
$81.0M
FUNCTIONAL PROTEOMICS OF LEUKEMIC MARROW STROMAL CELLSR33CA092731 · NCI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SESHI, BEERELLI · 2006 to 2011
$1.1M
FUNCTIONAL PROTEOMICS OF LEUKEMIC MARROW STROMAL CELLSR21CA092731 · NCI · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI SESHI, BEERELLI · 2002 to 2003
$254k
Intramural NIH HHS Z99 CA999999Wellcome TrustWellcome Trust 092731World Health Organization 001
6 · The paper itself

Abstract

backgroundChildhood cancer is a rare but leading cause of morbidity and mortality. Established risk factors, accounting for <10% of incidence, have been identified primarily from case-control studies. However, recall, selection and other potential biases impact interpretations particularly, for modest associations. A consortium of pregnancy and birth cohorts (I4C) was established to utilise prospective, pre-diagnostic exposure assessments and biological samples.

methodsEligibility criteria, follow-up methods and identification of paediatric cancer cases are described for cohorts currently participating or planning future participation. Also described are exposure assessments, harmonisation methods, biological samples potentially available for I4C research, the role of the I4C data and biospecimen coordinating centres and statistical approaches used in the pooled analyses.

resultsCurrently, six cohorts recruited over six decades (1950s-2000s) contribute data on 388 120 mother-child pairs. Nine new cohorts from seven countries are anticipated to contribute data on 627 500 additional projected mother-child pairs within 5 years. Harmonised data currently includes over 20 "core" variables, with notable variability in mother/child characteristics within and across cohorts, reflecting in part, secular changes in pregnancy and birth characteristics over the decades.

conclusionsThe I4C is the first cohort consortium to have published findings on paediatric cancer using harmonised variables across six pregnancy/birth cohorts. Projected increases in sample size, expanding sources of exposure data (eg, linkages to environmental and administrative databases), incorporation of biological measures to clarify exposures and underlying molecular mechanisms and forthcoming joint efforts to complement case-control studies offer the potential for breakthroughs in paediatric cancer aetiologic research.

Indexed as

Child HealthAdolescentAge of OnsetBiasChildChild, PreschoolDatabases, FactualEnvironmental ExposureHumansInfantInfant, NewbornLife StyleNeoplasmsOdds RatioProspective StudiesRisk Factorsbirth cohortchildhood cancerenvironmental exposuresInternational Childhood Cancer Cohort Consortium (I4C)leukaemialife style factorsrecall biasselection bias

Identifiers

PMID30466188
PMCPMC11155068

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.