Evidence map›Paper›PMID 30465880›Full record

ArticleBrain, behavior, and immunity2019

Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice.

Sarah A Woller, Cody Ocheltree, Stephanie Y Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves Dos Santos, Tony L Yaksh, Maripat Corr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

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  18. Neuraxial Cytokines in Pain States.Frontiers in immunology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sarah A WollerDepartments of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Cody OcheltreeDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.
Stephanie Y WongDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.
Anthony BuiDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.
Yuya FujitaDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.
Gilson Gonçalves Dos SantosDepartments of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Tony L YakshDepartments of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Maripat CorrDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA. Electronic address: mpcorr@ucsd.edu.
University of California San Diego · US

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
AIBP and regulation of neuropathic painR01NS102432 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY, YAKSH, TONY L. · 2017 to 2021
$3.0M
Sex, Stress and Immunity in the Acute to Chronic Pain TransitionR01NS099338 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 2017 to 2021
$1.8M
NIAMS NIH HHS T32 AR064194NINDS NIH HHS R01 NS099338NINDS NIH HHS R01 NS102432
6 · The paper itself

Abstract

In rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition to the post-inflammatory phenotype is dependent on TLR4 signaling. At the spinal level, we found differences in TNF and IFNβ mRNA expression in WT and TLR4 deficient males. In wild type male and female mice, there is differential temporal spinal expression of TNF and IFNβ. In WT males, blockade of TNF or administration of IFNβ was insufficient to affect the persistent allodynia. However, co-administration of intrathecal (IT) IFNβ and anti-TNF antibodies in male WT mice permanently reversed tactile allodynia. IT IFNβ treatment induces expression of anti-inflammatory proteins, contributing to the beneficial effect. Together, these experiments illustrated differences in the transition to chronic tactile allodynia in male and female animals and the complexities of effective pharmacologic interventions.

Indexed as

AnimalsArthritisArthritis, RheumatoidCentral Nervous SystemDisease Models, AnimalFemaleHyperalgesiaInterferon-betaMaleMiceMice, Inbred C57BLPainSex FactorsSignal TransductionToll-Like Receptor 4Tumor Necrosis Factor-alphaInterferon-betaTlr4 protein, mouseToll-Like Receptor 4Tumor Necrosis Factor-alphaAllodyniaArthritisInterferonSex differencesToll-like receptors

Identifiers

PMID30465880
PMCPMC6396982
OpenAlexW2900757229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.