ArticleThe British journal of radiology2019
An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Establishment and characterization of an orthotopic implanted lung cancer model to mimic human tumor structure, microenvironment, and metastatic spread.Translational lung cancer research · 2025Article
- Orthotopic and metastatic tumour models in preclinical cancer research.Pharmacology & therapeutics · 2024Review
- A novel orthotopic mouse model replicates human lung cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2023Article
- Article
- Inter-observer variability of organ contouring for preclinical studies with cone beam Computed Tomography imaging.Physics and imaging in radiation oncology · 2022Article
- Deep Learning Based Automated Orthotopic Lung Tumor Segmentation in Whole-Body Mouse CT-Scans.Cancers · 2021Article
- Article
- In Vivo Bioluminescence Tomography Center of Mass-Guided Conformal Irradiation.International journal of radiation oncology, biology, physics · 2020Article
- MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?Frontiers in oncology · 2020Review
- Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models.Frontiers in nutrition · 2020Review
- Preclinical models of radiation-induced lung damage: challenges and opportunities for small animal radiotherapy.The British journal of radiology · 2019Review
- Integrating Small Animal Irradiators withFunctional Imaging for Advanced Preclinical Radiotherapy Research.Cancers · 2019Review
- Radiation-Induced Lung Injury (RILI).Frontiers in oncology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
methods: An orthotopic non-small cell lung cancer model in NMRI-nude mice was established to investigate the complementary information acquired from 80 kVp microcone-beam CT (micro-CBCT) and bioluminescence imaging (BLI) using different angles and filter settings. Different micro-CBCT-based radiation-delivery plans were evaluated based on their dose-volume histogram metrics of tumor and organs at risk to select the optimal treatment plan.
results: H1299 cell suspensions injected directly into the lung render exponentially growing single tumor nodules whose CBCT-based volume quantification strongly correlated with BLI-integrated intensity. Parallel-opposed single angle beam plans through a single lung are preferred for smaller tumors, whereas for larger tumors, plans that spread the radiation dose across healthy tissues are favored.
conclusions: Closely mimicking a clinical setting for lung cancer with highly advanced preclinical radiation treatment planning is possible in mice developing orthotopic lung tumors. ADVANCES IN KNOWLEDGE:: BLI and CBCT imaging of orthotopic lung tumors provide complementary information in a temporal manner. The optimal radiotherapy plan is tumor volume-dependent.
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