Evidence map›Paper›PMID 30465652›Full record

ArticleeLife2018

Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting.

Jiyu Wang, Jie Zhou, Qidi Yang, Elizabeth J Grayhack

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

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  8. Genome-Wide Analysis ofInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jiyu WangDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York.ORCID http://orcid.org/0000-0002-1283-2934
Jie ZhouDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York.
Qidi YangDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York.
Elizabeth J GrayhackDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York.ORCID https://orcid.org/0000-0003-2400-5490
University of Rochester · US

Funding

Modulation of translation by synonymous codons in yeastR01GM118386 · NIGMS · UNIVERSITY OF ROCHESTER · PI GRAYHACK, ELIZABETH JOAN · 2016 to 2023
$2.5M
QExactive for UR Proteomics ResearchS10OD021486 · OD · UNIVERSITY OF ROCHESTER · PI GHAEMMAGHAMI, SINA · 2016 to 2016
$309k
NIGMS NIH HHS R01 GM118386NIH HHS R01 GM118386NIH HHS S10 OD021486
6 · The paper itself

Abstract

Reading frame maintenance is critical for accurate translation. We show that the conserved eukaryotic/archaeal protein Mbf1 acts with ribosomal proteins Rps3/uS3 and eukaryotic Asc1/RACK1 to prevent frameshifting at inhibitory CGA-CGA codon pairs in the yeast

Indexed as

Protein BiosynthesisAdaptor Proteins, Signal TransducingBase SequenceCodonFrameshifting, RibosomalGTP-Binding ProteinsInternal Ribosome Entry SitesOpen Reading FramesRibosomal ProteinsRibosomesRNA, MessengerRNA StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence AlignmentSequence Homology, Nucleic AcidAdaptor Proteins, Signal TransducingASC1 protein, S cerevisiaeCodonGTP-Binding ProteinsInternal Ribosome Entry SitesMBF1 protein, S cerevisiaeRibosomal ProteinsRNA, MessengerRPS3 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsAsc1/RACK1chromosomesframeshiftinggene expressionMbf1ribosomeRps3S. cerevisiaetranslation

Identifiers

PMID30465652
PMCPMC6301793
OpenAlexW2951199532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.