ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Obstructive sleep apnea during REM sleep and daytime cerebral functioning: A regional cerebral blood flow study using high-resolution SPECT.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Umbilical cord blood biomarkers of neuronal injury in sleep-disordered breathing during pregnancy.Scientific reports · 2026Article
- Altered brain glucose metabolism and connectivity in young adults with obstructive sleep apnea.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Hypoxemia Due to Obstructive Sleep Apnea With White Matter Hyperintensities and Temporal Lobe Changes in Older Adults.Neurology · 2025Observational
- Sleep macro-architecture, nocturnal hypoxemia, and Alzheimer's disease-related MRI patterns among diverse older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Differential analysis of clinical outcomes in cerebral infarction associated with REM-OSA and NREM-OSA: a retrospective database study.Frontiers in neurology · 2025Article
- Article
- Hypoxemia during rapid eye movement sleep mediates memory impairment in older adults at risk for dementia via CA1 hippocampal volume loss.European journal of neurology · 2024Article
- Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity in REM sleep and verbal memory.Alzheimer's research & therapy · 2024Article
- Impaired declarative memory consolidation in children with REM sleep-related obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- The impact of a 12-week tele-exercise program on cognitive function and cerebral oxygenation in patients with OSA: randomized controlled trial-protocol study.Frontiers in sports and active living · 2024Article
- Abnormal changes in neuropsychological function, brain structure and cerebral perfusion in patients with unruptured intracranial aneurysms.Frontiers in neurology · 2024Article
- Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity and verbal memory.Research square · 2023Article
- Neurocognitive, mood changes, and sleepiness in patients with REM-predominant obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2023Review
- Altered cerebral blood flow and white matter during wakeful rest in patients with obstructive sleep apnea: a population-based retrospective study.The British journal of radiology · 2023Article
- Development and validation of prediction models for neurocognitive disorders in adult patients admitted to the ICU with sleep disturbance.CNS neuroscience & therapeutics · 2022Article
- Longitudinal changes in regional cerebral blood flow in late middle-aged and older adults with treated and untreated obstructive sleep apnea.Human brain mapping · 2021Article
- Obstructive Sleep Apnea and Cognitive Decline: A Review of Potential Vulnerability and Protective Factors.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) predominantly during rapid eye movement (REM) sleep may have impacts on brain health, even in milder OSA cases. Here, we evaluated whether REM sleep OSA is associated with abnormal daytime cerebral functioning using high-resolution single-photon emission computed tomography (SPECT). We tested 96 subjects (25 F, age: 65.2 ± 6.4) with a wide range of OSA severity from no OSA to severe OSA (apnea-hypopnea index: 0-97 events/h). More respiratory events during REM sleep were associated with reduced daytime regional cerebral blood flow (rCBF) in the bilateral ventromedial prefrontal cortex and in the right insula extending to the frontal cortex. More respiratory events during non-REM (NREM) sleep were associated with reduced daytime rCBF in the left sensorimotor and temporal cortex. In subjects with a lower overall OSA severity (apnea-hypopnea index<15), more respiratory events during REM sleep were also associated with reduced daytime rCBF in the insula and extending to the frontal cortex. Respiratory events that characterized OSA during NREM versus REM sleep are associated with distinct patterns of daytime cerebral perfusion. REM sleep OSA could be more detrimental to brain health, as evidenced by reduced daytime rCBF in milder forms of OSA.
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