ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2019
Resting-state MEG measurement of functional activation as a biomarker for cognitive decline in MS.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Neurophysiological brain function predicts response to cognitive rehabilitation and mindfulness in multiple sclerosis: a randomized trial.Journal of neurology · 2024Trial
- Frontal brain activity and cognitive processing speed in multiple sclerosis: An exploration of EEG neurofeedback training.NeuroImage. Clinical · 2019Trial
- Functional Connectivity at Rest and During Cognitive Processing in Multiple Sclerosis: A Pilot Magnetoencephalography Study and Systematic Review.Brain sciences · 2026Article
- Article
- Preserved α2 oscillations underpin reserve-related resilience of semantic verbal fluency in multiple sclerosis.Frontiers in neuroscience · 2026Article
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Alternations of neuromagnetic activity across neurocognitive core networks among benign childhood epilepsy with centrotemporal spikes: A multi-frequency MEG study.Frontiers in neuroscience · 2023Article
- Multistage classification identifies altered cortical phase- and amplitude-coupling in Multiple Sclerosis.NeuroImage · 2022Article
- Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Structure-function coupling as a correlate and potential biomarker of cognitive impairment in multiple sclerosis.Network neuroscience (Cambridge, Mass.) · 2022Article
- Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- State Changes During Resting-State (Magneto)encephalographic Studies: The Effect of Drowsiness on Spectral, Connectivity, and Network Analyses.Frontiers in neuroscience · 2022Article
- Brain dysconnectivity relates to disability and cognitive impairment in multiple sclerosis.Human brain mapping · 2021Article
- Neurophysiological and olfactory biomarkers for multiple sclerosis.Nature reviews. Neurology · 2019Article
- Brain Functional Connectivity Through Phase Coupling of Neuronal Oscillations: A Perspective From Magnetoencephalography.Frontiers in neuroscience · 2019Review
Corrections and comments
- Commented on by
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurophysiological measures of brain function, such as magnetoencephalography (MEG), are widely used in clinical neurology and have strong relations with cognitive impairment and dementia but are still underdeveloped in multiple sclerosis (MS).
objectivesTo demonstrate the value of clinically applicable MEG-measures in evaluating cognitive impairment in MS.
methodsIn eyes-closed resting-state, MEG data of 83 MS patients and 34 healthy controls (HCs) peak frequencies and relative power of six canonical frequency bands for 78 cortical and 10 deep gray matter (DGM) areas were calculated. Linear regression models, correcting for age, gender, and education, assessed the relation between cognitive performance and MEG biomarkers.
resultsIncreased alpha1 and theta power was strongly associated with impaired cognition in patients, which differed between cognitively impaired (CI) patients and HCs in bilateral parietotemporal cortices. CI patients had a lower peak frequency than HCs. Oscillatory slowing was also widespread in the DGM, most pronounced in the thalamus.
conclusionThere is a clinically relevant slowing of neuronal activity in MS patients in parietotemporal cortical areas and the thalamus, strongly related to cognitive impairment. These measures hold promise for the application of resting-state MEG as a biomarker for cognitive disturbances in MS in a clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.