Observational studyThe Journal of international medical research2019
Biochemical changes associated with temporomandibular disorders.
Observational study in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Biomarkers in Temporomandibular Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Pooled it
- Association of vitamin D status with the presence of Temporomandibular Disorder (TMD): a case-control study.BMC oral health · 2026Article
- Salivary and serum biomarkers profile of patients with rheumatoid arthritis and temporomandibular disorders.Clinical rheumatology · 2025Article
- Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights.Nutrients · 2024Review
- Efficacy of acupuncture on craniomandibular myofascial pain in temporomandibular disorder patients: A systematic review.Heliyon · 2024Article
- Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review).Experimental and therapeutic medicine · 2023Review
- Vitamin DInternational journal of molecular sciences · 2023Review
- Is the Prevalence of Vitamin D deficiency in Patients with Temporomandibular Disorder Higher than Healthy Control Group?Journal of maxillofacial and oral surgery · 2022Article
- Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review.Journal of clinical medicine · 2022Review
- Role of osteoclast differentiation in the occurrence of osteoarthritis of temporomandibular joint.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- A comprehensive review on biomarkers associated with painful temporomandibular disorders.International journal of oral science · 2021Review
- Review
- The Association between Temporomandibular Disorder and Sleep Apnea-A Nationwide Population-Based Cohort Study.International journal of environmental research and public health · 2020Article
- Serum Analysis in Patients with Temporomandibular Disorders: A Controlled Cross-Sectional Study in Norway.Pain research & management · 2019Article
- Biomarkers in orofacial pain conditions: A narrative review.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess vitamin D, parathyroid hormone, calcitonin, calcium, phosphorus and magnesium levels in patients with versus without temporomandibular disorders (TMDs).
methodsThis prospective observational study included patients with TMDs and age-matched healthy controls. TMDs were diagnosed via physical and radiologic examination, and serum levels of 25 (OH) vitamin D, parathyroid hormone, calcitonin, calcium, magnesium, and phosphorus were determined. The impact of age, sex and seasonal variations in serum 25 (OH) vitamin D levels was controlled by the inclusion of age, sex and date-matched control patients.
resultsThe study included 100 patients, comprising 50 patients with TMDs and 50 control patients. No statistically significant between-group differences were found regarding age or sex. No statistically significant between-group differences were found in terms of serum 25 (OH) vitamin D, calcitonin, calcium, magnesium or phosphorus levels. Parathyroid hormone levels were statistically significantly higher in patients with TMDs versus healthy control patients.
conclusionIn patients with temporomandibular disorders, increased parathyroid hormone levels in response to vitamin D deficiency was significantly more prominent. These data suggest that, in patients with temporomandibular disorders, vitamin D deficiency should be assessed and corrected.
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