SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Patient-reported outcomes in stroke clinical trials 2002-2016: a systematic review.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Determining optimal strategies for primary prevention of cardiovascular disease: a synopsis of an evidence synthesis study.Health technology assessment (Winchester, England) · 2025 · on this mapPooled it
- A randomized control trial of the effects of home-based online attention training and working memory training on cognition and everyday function in a community stroke sample.Neuropsychological rehabilitation · 2022Trial
- Sex Differences in Patient Reported Outcome Measures after Stroke: What's New and What's Next?Current neurology and neuroscience reports · 2025Review
- Determinants of post-stroke cognitive impairment and dementia: association with objective measures and patient-reported outcomes.Frontiers in stroke · 2023Article
- Psychometric properties of the Chinese (Cantonese) version of the Upper Extremity Functional Index in people with chronic stroke.Frontiers in neurology · 2023Article
- Disparities in Stroke Patient-Reported Outcomes Measurement Between Healthcare Systems in Brazil.Frontiers in neurology · 2022Article
- The PostStroke-Manager - combining mobile, digital and sensor-based technology with personal assistance: protocol of the feasibility study.Neurological research and practice · 2021Article
- Psychometric properties of a patient-reported outcome set in acute stroke patients.Brain and behavior · 2021Article
- The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.Pharmaceutical research · 2021Article
- Changes of Health-Related Quality of Life Within the 1st Year After Stroke-Results From a Prospective Stroke Cohort Study.Frontiers in neurology · 2021Article
- Registered Reports at "Quality of Life Research".Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Differential Effects of Time to Initiation of Therapy on Disability and Quality of Life in Patients With Mild and Moderate to Severe Ischemic Stroke.Archives of physical medicine and rehabilitation · 2020Observational
- Validation of the Spanish Version of Newcastle Stroke-Specific Quality of Life Measure (NEWSQOL).International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGiven the global and economic burden of stroke as a major cause of long-term disability, patient-reported outcomes (PRO) data from clinical trials can elucidate differential benefits/harms of interventions from patients' perspectives and influence clinical decision making in stroke care management.
methodsThis systematic review examines stroke-related randomized controlled trials (RCT) published in 12 high-impact journals between 2002 and 2016 for (1) associations between trial characteristics and the reporting of PRO measures; and (2) psychometric properties of PRO instruments used in these studies. The study combines clinical trials identified in a prior review with trials identified with an updated literature search.
resultsOnly 34 of 159 stroke-related RCTs reported PRO measures. Among the 34 trials, most were published in rehabilitation and general medical journals, were conducted in the United States or Europe, were funded by government/non-industry sponsors, and focused on post-stroke care. Thirty-one PRO instruments were employed in these studies. Only 5 instruments were stroke-specific measures, whereas the remaining 26 instruments were generic measures. Eight instruments assessed functional status, 9 measured quality of life, and 14 assessed symptoms. The most common health domains measured were emotional status and physical function.
conclusionsThis study highlights the paucity of information from patients' perspective in stroke-related RCTs. This trend may change over time as researchers increase adherence to reporting guidelines for clinical trial protocols.
Indexed as
Identifiers
30465318What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.