ArticleRice (New York, N.Y.)2018
Genome-wide association study and candidate gene analysis of rice cadmium accumulation in grain in a diverse rice collection.
Article in Rice (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 160 citations in OpenAlex.
- Integrative genomics resolves rice loci associated with acidic soil-related aluminum, cadmium, and manganese stress responses.Plant cell reports · 2026Article
- Molecular Evolution and Mechanisms of Plants NRAMP Transporters in Response to Heavy Metal Stress.Plants (Basel, Switzerland) · 2026Review
- The MATE family transporter CaDTX12 confers cadmium accumulation in pepper (Capsicum annuum L.).Functional & integrative genomics · 2025Article
- Navigating the genetic basis of cadmium accumulation: a comprehensive analysis of low-cadmium accumulation rice.Molecular breeding : new strategies in plant improvement · 2025Article
- A multi-omics analysis reveals candidate genes for Cd tolerance in Paspalum vaginatum.BMC plant biology · 2025Article
- A Major Latex Protein-Encoding Gene fromInternational journal of molecular sciences · 2025Article
- Elite Alleles of EPE1 Identified via Genome-wide Association Studies Increase Panicle Elongation Length in Rice.Rice (New York, N.Y.) · 2025Article
- QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis.BMC plant biology · 2025Article
- Defense guard: strategies of plants in the fight against Cadmium stress.Advanced biotechnology · 2024Review
- Exploring genotypic variation and gene expression associated to cadmium accumulation in bread wheat.Scientific reports · 2024Article
- A Novel Function of GW5 on Controlling the Early Growth Vigor and its Haplotype Effect on Shoot Dry Weight and Grain Size in Rice (Oryza sativa L.).Rice (New York, N.Y.) · 2024Article
- Article
- Pangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice.Rice (New York, N.Y.) · 2024Article
- Physiological and biochemical characteristics of high and low Cd accumulating Brassica napus genotypes.Environmental science and pollution research international · 2024Article
- Article
- Engineering rice Nramp5 modifies cadmium and manganese uptake selectivity using yeast assay system.Frontiers in plant science · 2024Article
- Advances in epigenetic studies of plant cadmium stress.Frontiers in plant science · 2024Review
- Identification of Candidate Genes that Affect the Contents of 17 Amino Acids in the Rice Grain Using a Genome-Wide Haplotype Association Study.Rice (New York, N.Y.) · 2023Article
- Cadmium Absorption in Various Genotypes of Rice under Cadmium Stress.International journal of molecular sciences · 2023Article
- Transcriptional Regulatory Network of Plant Cadmium Stress Response.International journal of molecular sciences · 2023Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCadmium (Cd) accumulation in rice followed by transfer to the food chain causes severe health problems in humans. Breeding of low Cd accumulation varieties is one of the most economical ways to solve the problem. However, information on the identity of rice germplasm with low Cd accumulation is limited, particularly in indica, and the genetic basis of Cd accumulation in rice is not well understood.
resultsScreening of 312 diverse rice accessions revealed that the grain Cd concentrations of these rice accessions ranged from 0.12 to 1.23 mg/kg, with 24 accessions less than 0.20 mg/kg. Three of the 24 accessions belong to indica. Japonica accumulated significantly less Cd than indica (p < 0.001), while tropical japonica accumulated significantly less Cd than temperate japonica (p < 0.01). GWAS in all accessions identified 14 QTLs for Cd accumulation, with 7 identified in indica and 7 identified in japonica subpopulations. No common QTL was identified between indica and japonica. The previously identified genes (OsHMA3, OsNRAMP1, and OsNRAMP5) from japonica were colocalized with QTLs identified in japonica instead of indica. Expression analysis of OsNRAMP2, the candidate gene of the novel QTL (qCd3-2) identified in the present study, demonstrated that OsNRAMP2 was mainly induced in the shoots of high Cd accumulation accessions after Cd treatment. Four amino acid differences were found in the open reading frame of OsNRAMP2 between high and low Cd accumulation accessions. The allele from low Cd accumulation accessions significantly increased the Cd sensitivity and accumulation in yeast. Subcellular localization analysis demonstrated OsNRAMP2 expressed in the tonoplast of rice protoplast.
conclusionThe results suggest that grain Cd concentrations are significantly different among subgroups, with Cd concentrations decreasing from indica to temperate japonica to tropical japonica. However, considerable variations exist within subgroups. The fact that no common QTL was identified between indica and japonica implies that there is a different genetic basis for determining Cd accumulation between indica and japonica, or that some QTLs for Cd accumulation in rice are subspecies-specific. Through further integrated analysis, it is speculated that OsNRAMP2 could be a novel functional gene associated with Cd accumulation in rice.
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