Evidence map›Paper›PMID 30465236›Full record

ArticleOphthalmology and therapy2019

Near Vision Improvement with the Use of a New Topical Compound for Presbyopia Correction: A Prospective, Consecutive Interventional Non-Comparative Clinical Study.

Veronica Vargas, Felipe Vejarano, Jorge L Alió

Open access · goldAbstract read
In one paragraph

Article in Ophthalmology and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Presbyopia: Current Perspectives and Prospects for Patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  3. A Comparative Clinical Study of 0.50% Versus 0.75% Pilocarpine Eye Drops for Improving Visual Performance in Presbyopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  4. The Science of Pseudoaccommodation and Its Therapeutic Potential.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
  5. Article
  6. Article
  7. Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients.Journal of ophthalmic & vision research · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Correction of presbyopia.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  13. Pharmacological treatment of presbyopia: A systematic review.European journal of translational myology · 2022
    Article
  14. Pharmacological Treatment in Presbyopia.Journal of clinical medicine · 2022
    Review
  15. A multicentric study of pharmacological treatment for presbyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  16. Review
  17. Article
  18. Presbyopia Treatment With Eye Drops: An Eight Year Retrospective Study.Translational vision science & technology · 2020
    Article
  19. Review
  20. A Review of Pharmacological Presbyopia Treatment.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Veronica VargasVissum Instituto Oftalmologico de Alicante, Alicante, Spain.
Felipe VejaranoFundacion Oftalmologica Vejarano, Popayan, Colombia.
Jorge L AlióVissum Instituto Oftalmologico de Alicante, Alicante, Spain. jlalio@vissum.com.
Miranza · ESFundación Universitaria de Popayán · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo report the outcomes in near vision, optical quality and pupil diameter of a new pharmacological therapy (FOV tears) for presbyopia.

methodsThis was a prospective, consecutive, interventional, non-comparative clinical study in which 117 presbyopic patients were given one drop of the novel therapy (FOV tears) in each eye, followed 2 h after the instillation of the eye drop by an evaluation of the binocular uncorrected near visual acuity (UNVA) and uncorrected distance visual acuity. The objective scatter index and pupil diameter under photopic and scotopic conditions before and after instillation were also assessed. The patients were divided into two groups according to their age, with group 1 patients being 41 and 50 years old and group 2 patients, between 51 and 65 years old.

resultsThe mean age of the patients was 50.2 years. The mean UNVA before the use of the eye drop was 0.35 LogMAR, which improved to 0.16 LogMAR at 2 h after the use of the eye drop (p = 0.000). Nine patients did not show an improvement in UNVA, but no patient showed a loss of lines. Fourteen patients (11.9%) reported headaches as a side effect of the therapy.

conclusionThis pharmacological therapy improved near vision by one or more lines (mean improvement 0.18 lines) in 92.3% of the patients at 2 h following the instillation of the eye drops. The group with the youngest patients gained more lines than the group with the oldest patients.

Indexed as

AccommodationDepth of focusNear visionObjective scatter indexPharmacological treatmentPresbyopiaPupil sizeRefractive surgery

Identifiers

PMID30465236
PMCPMC6393255
OpenAlexW2900760639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.