Evidence map›Paper›PMID 30465194›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells.

Xiaoniao Chen, Fengyang Lei, Liqiang Wang, Xiaofang Xiong, Jianxun Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Xiaoniao ChenDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
Fengyang LeiDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Liqiang WangDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
Xiaofang XiongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University University Health Science Center, College Station, TX, USA.
Jianxun SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University University Health Science Center, College Station, TX, USA. jus35@tamu.edu.
Chinese PLA General Hospital · CNTexas A&M Health Science Center · USHarvard University · US

Funding

Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyR01CA221867 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2018 to 2023
$2.8M
Stem cell-derived regulatory T cells for therapeutic use in arthritisR01AI121180 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2016 to 2020
$1.9M
Directed differentiation of HBV-specific CTL from iPSC for cell-based therapiesR21AI109239 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SONG, JIANXUN JIM · 2014 to 2015
$441k
NCI NIH HHS R01 CA221867NIAID NIH HHS R01 AI121180NIAID NIH HHS R21 AI109239
6 · The paper itself

Abstract

Immunotherapy is a developing but very promising arsenal to treat cancer. Acquiring a more potent and effective approach in cancer immunotherapy is always the ultimate pursuance. CTL-based therapies are highly acclaimed recently due to its direct killing property. However, difficulty in obtaining adequate number of CTLs is still a major obstacle. In previous studies, it is shown that pluripotent stem cell-derived cytotoxic T lymphocytes (CTL)-especially the genetically engineered tumor antigen-specific CTLs-may serve as a good candidate for this goal. Here we introduce a novel approach in generating tumor antigen-specific CTLs from induced pluripotent stem cells (iPSCs) by using both in vitro and in vivo priming mechanisms for the tumor management in a murine melanoma model.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntigens, NeoplasmCalcium-Binding ProteinsCell Culture TechniquesCell DifferentiationCell Line, TumorFemaleImmunotherapy, AdoptiveInduced Pluripotent Stem CellsIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsIntramolecular OxidoreductasesMelanoma, ExperimentalMembrane ProteinsMiceAdaptor Proteins, Signal TransducingAntigens, NeoplasmCalcium-Binding ProteinsDlk1 protein, mouseDLL4 protein, mousedopachrome isomeraseIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsIntramolecular OxidoreductasesMembrane ProteinsReceptors, Antigen, T-CellCytotoxic T lymphocytesImmunotherapyMelanomaNotch signalingPluripotent stem cells

Identifiers

PMID30465194
PMCPMC6629431
OpenAlexW2901683845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.