Evidence map›Paper›PMID 30465125›Full record

ReviewWorld journal of pediatrics : WJP2019

Liver fibrosis in biliary atresia.

Wen-Jun Shen, Gong Chen, Min Wang, Shan Zheng

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of pediatrics : WJP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  12. Article
  13. Biliary atresia-related liver fibrosis.Frontiers in cell and developmental biology · 2026
    Review
  14. Article
  15. Late Referral of Biliary Atresia and Poor Clinical Outcomes.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Observational
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wen-Jun ShenDepartment of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Gong ChenDepartment of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Min WangDepartment of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Shan ZhengDepartment of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, 201102, China. szheng@shmu.edu.cn.
Children's Hospital of Fudan University · CN

Funding

National Natural Science Foundation of China 81400576
6 · The paper itself

Abstract

backgroundBiliary atresia (BA) is the most common cause of obstructive jaundice in infants. Although the Kasai procedure has greatly improved the prognosis, most patients still need liver transplantation (LT) for long-term survival. The pathogenesis of BA has not been fully clarified, and liver fibrosis in BA is far beyond biliary obstructive cirrhosis. DATA SOURCES: Literature reviews were underwent through PubMed. Persistent inflammation, immune response, biliary epithelial-mesenchymal transition, matrix deposition, decompensated angiogenesis, and unique biliary structure development all contribute to the fibrosis process. Observed evidences in such fields have been collected and form the backbone of this review.

resultsInteractions of the multiple pathways accelerate this process.

conclusionsUnderstanding the mechanisms of the liver fibrosis in BA may pave the way to improved survival after the Kasai procedure.

Indexed as

Biliary AtresiaCause of DeathDisease ProgressionFemaleHumansInfantInfant, NewbornJaundice, ObstructiveLiver CirrhosisLiver TransplantationMalePortoenterostomy, HepaticPrognosisRisk AssessmentSurvival AnalysisBiliary atresiaChildrenLiver fibrosis

Identifiers

PMID30465125
OpenAlexW2901531097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.