Evidence map›Paper›PMID 30465089›Full record

ArticleJournal of bone and mineral metabolism2019

miR-195 contributes to human osteoarthritis via targeting PTHrP.

Xiaoming Cao, Zhiqing Duan, Zheyi Yan, Yongping Li, Lu Li, Jian Sun, Pengfei Han, Pengcui Li, Lei Wei, Xiaochun Wei

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of bone and mineral metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Crosstalk Among circRNA/lncRNA, miRNA, and mRNA in Osteoarthritis.Frontiers in cell and developmental biology · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Xiaoming CaoDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Zhiqing DuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Medical University, 56 South Xinjian Road, Taiyuan, 030001, Shanxi, China.
Zheyi YanDepartment of Ophthalmology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Yongping LiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Lu LiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Jian SunDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Pengfei HanDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Pengcui LiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Lei WeiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.
Xiaochun WeiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China. sdeygksys@163.com.ORCID http://orcid.org/0000-0002-6175-4346

Funding

Construction of resource sharing platform for osteoarthritis in Shanxi province 201705D121010National International Science and Technology Cooperation Project 2015DFA33050
6 · The paper itself

Abstract

The dysregulated expression of the osteoarthritis (OA)-related genes in cartilage, such as matrix metalloproteinase 13 (MMP-13) and type X collagen (Col X), facilitates the onset and progression of OA. Reduced parathyroid hormone-related protein (PTHrP) may also accelerate this progression. Furthermore, miRNAs, endogenous regulators of mRNAs, are thought to play key roles in the pathogenesis of OA. In this study, we found that miR-195 levels were significantly upregulated in OA tissue, while PTHrP mRNA/protein expression was substantially downregulated, and there was a negative correlation between miR-195 and PTHrP. Upregulated miR-195 strongly inhibited Aggrecan, type II collagen (Col II) mRNA/protein expression, while it enhanced the expression of MMP-13 and Col X at mRNA/protein level; conversely, downregulated miR-195 significantly increased Col II mRNA/protein expression, while it decreased the expression of MMP-13 and Col X mRNA/protein. Moreover, our study demonstrated that PTHrP is a novel target of miR-195 using dual luciferase reporter assay. Finally, miR-195-mediated changes of Col II and OA-related genes were substantially attenuated by siRNA

Indexed as

AgedBase SequenceCartilage, ArticularCase-Control StudiesCells, CulturedChondrocytesFemaleGene Expression RegulationHumansMaleMicroRNAsMiddle AgedOsteoarthritisParathyroid Hormone-Related ProteinMicroRNAsMIRN195 microRNA, humanParathyroid Hormone-Related ProteinPTHLH protein, humanmiR-195MMP-13PTHrPType II collagenType X collagen

Identifiers

PMID30465089

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.