ArticleWorld journal of surgery2019
Bone Mineral Density as a Risk Factor for Patients Undergoing Surgery for Hepatocellular Carcinoma.
Article in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictive value of osteopenia as prognostic marker for survival and recurrence in patients with gastrointestinal cancers: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prognostic value of preoperative low bone mineral density in patients with digestive cancers: a systematic review and meta-analysis.Archives of osteoporosis · 2022Pooled it
- Liver Cancer Bone Metastasis: Molecular Mechanisms and Therapeutic Insights.Current topics in medicinal chemistry · 2026Review
- Improved Osteoporosis Prediction in Breast Cancer Patients Using a Novel Semi-Foundational Model.Journal of imaging informatics in medicine · 2025Article
- Article
- Osteosarcopenia as a Predictor of Histopathologic Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer: a Retrospective Cohort Study.Langenbeck's archives of surgery · 2025Article
- The Incidence of Osteoporosis in Hepatocellular Carcinoma Patients Under 65: A Retrospective Cohort Study.Cureus · 2025Article
- Prognostic impact of preoperative osteosarcopenia on esophageal cancer surgery outcomes: a retrospective analysis.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- Bone mineral density predicts survival in patients with hepatocellular carcinoma and portal vein tumor thrombosis.PloS one · 2025Article
- Clinical impact of low bone mineral density in patients with colorectal cancer liver metastasis undergoing hepatectomy.PloS one · 2025Article
- Prognostic significance of osteosarcopenia in patients with stage IV gastric cancer undergoing conversion surgery.Langenbeck's archives of surgery · 2024Article
- Article
- Article
- Hepatocellular carcinoma and musculoskeletal system: A narrative literature review.World journal of gastroenterology · 2024Review
- Impact of osteopenia and osteosarcopenia on the outcomes after surgery of hepatobiliary-pancreatic cancers.Frontiers in oncology · 2024Article
- Combined Bone Mineral Density (BMD) and Monocyte-to-Lymphocyte Ratio (MLR) Predicts Recurrence and Prognosis in Hepatocellular Carcinoma Patients Following Liver Resection.Risk management and healthcare policy · 2024Article
- Bone Lesion-Derived Extracellular Vesicles Fuel Prometastatic Cascades in Hepatocellular Carcinoma by Transferring ALKBH5-Targeting miR-3190-5p.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Prognostic significance of preoperative osteopenia on outcomes after gastrectomy for gastric cancer.Annals of gastroenterological surgery · 2023Article
- Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma.Current oncology (Toronto, Ont.) · 2023Article
- Osteopenia is associated with inferior survival in patients undergoing partial hepatectomy for hepatocellular carcinoma.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have reported the impact of sarcopenia and body composition on patients undergoing hepatectomy for hepatocellular carcinoma (HCC). However, the impact of bone mineral density (BMD) on outcomes after hepatectomy for HCC and correlation with other parameters including sarcopenia are unclear.
methodsWe retrospectively analyzed 465 patients who underwent primary hepatectomy for HCC between April 2005 and March 2015. We analyzed the plain CT images at the level of the eleventh thoracic vertebra with the region of interest and defined as preoperative BMD.
resultsIn this cohort, male (n = 367) and female (n = 98) patients showed significant heterogeneity in age, body composition markers, tumor factors, peri-operative parameters and so on. The median preoperative BMD in male and female patients was 155 and 139 HU, respectively (P = 0.005). BMD was negatively correlated with age in female (r = -0.590, P < 0.001) and intramuscular adipose tissue content in both male and female (r = -0.332 and -0.359, respectively, P < 0.001). For males, BMD < 160 HU was associated with worse cancer-specific survival post-hepatectomy (P = 0.015). In contrast, females were not (P = 0.135). For male patients, multivariate analysis identified low BMD as an independent risk factor for death (hazard ratio 1.720, 95% confidence interval 1.038-2.922, P = 0.035) after hepatectomy for HCC.
conclusionPreoperative low BMD was an independent risk factor for cancer-specific mortality after hepatectomy for HCC.
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