Evidence map›Paper›PMID 30465084›Full record

ArticleWorld journal of microbiology & biotechnology2018

Evaluation of the sub-optimal induction strategies for heterologous proteins production by Pichia pastoris Mut

Luqiang Jia, Minjie Gao, Jian Yan, Shanshan Chen, Jiaowen Sun, Qiang Hua, Jian Ding, Zhongping Shi

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luqiang JiaThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China.
Minjie GaoThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China.
Jian YanThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China.
Shanshan ChenThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China.
Jiaowen SunThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China.
Qiang HuaState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jian DingThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China. dingjian@jiangnan.edu.cn.
Zhongping ShiThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China. jnbioprocess@163.com.
Jiangnan University · CNEast China University of Science and Technology · CN

Funding

Industry-Education-Research Cooperation Project of Jiangsu Province #BY2016022-15National first-class discipline program of Light Industry Technology and Engineering #2018-17National Natural Science Foundation of China #21606106Natural Science Foundation of Jiangsu Province #BK20150127the Fundamental Research Funds for the Central Universities #JUSRP11536the Fundamental Research Funds for the Central Universities #JUSRP51632A
6 · The paper itself

Abstract

Heterologous proteins induction by methylotrophic recombinant Pichia pastoris is generally implemented at high cells density condition. Methanol concentration (MeOH) and dissolved oxygen concentration (DO) are two crucial operating parameters controlling proteins production. It is difficult to control MeOH/DO at their desired levels simultaneously due to the extremely high oxygen consumption features. Methanol utilization plus (Mut

Indexed as

Gene Expression ProfilingBioreactorsFermentationGene Expression Regulation, FungalGranulocyte Colony-Stimulating FactorHumansInterferon-alphaMetabolic Networks and PathwaysMethanolOxygenOxygen ConsumptionPhenotypePichiaRecombinant ProteinsSerum AlbuminSorbitolGranulocyte Colony-Stimulating FactorInterferon-alphaMethanolOxygenRecombinant ProteinsSerum AlbuminSorbitolDissolved oxygenMethanol concentrationP. pastorisTranscriptome analysis

Identifiers

PMID30465084
OpenAlexW2901570355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.