Evidence map›Paper›PMID 30465083›Full record

ReviewCellular and molecular life sciences : CMLS2019

Heparan sulfate proteoglycan (HSPG) can take part in cell division: inside and outside.

Bettina Ughy, Ildiko Schmidthoffer, Laszlo Szilak

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bettina UghyInstitute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, 6726, Hungary.
Ildiko SchmidthofferAntal Wittmann Crop, Animal and Food Sciences Multidisciplinary Doctoral School, Mosonmagyaróvár, 9200, Hungary.
Laszlo SzilakSzilak Laboratories Bioinformatics and Molecule-Design Ltd., Szeged, 6723, Hungary. laszlo.szilak@gmail.com.ORCID http://orcid.org/0000-0003-0334-272X

Funding

Bolyai János Research Foundation of the Hungarian Academy of Science fellowshipHungarian National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00058New National Excellence Program of the Hungarian Ministry of Human Capacities. UNKP-18-4
6 · The paper itself

Abstract

Prior to the cytokinesis, the cell-matrix interactions should be disrupted, and the mitotic cells round up. Prerequisite of mitosis, the centrosomes duplicate, spindle fibers are generated and move away from each other to opposite sides of the cells marking the cell poles. Later, an invagination in the plasma membrane is formed a few minutes after anaphase. This furrow ingression is driven by a contractile actomyosin ring, whose assembly is regulated by RhoA GTPase. At the completion of cytokinesis, the two daughter cells are still connected by a thin intercellular bridge, which is subjected to abscission, as the terminal step of cytokinesis. Here, it is overviewed, how syndecan-4, a transmembrane, heparan sulfate proteoglycan, can contribute to these processes in a phosphorylation-dependent manner.

Indexed as

Cell DivisionActinsAnimalsCytokinesisHeparan Sulfate ProteoglycansHumansMitosisrhoA GTP-Binding ProteinSyndecan-4ActinsHeparan Sulfate ProteoglycansrhoA GTP-Binding ProteinSyndecan-4DynaminESCRTMicrotubulesMidbodyMitotic roundingPolyploidyProtein phosphorylationSmall GTPasesTiam1

Identifiers

PMID30465083
PMCPMC11105504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.