Evidence map›Paper›PMID 30465042›Full record

ArticleConditioning medicine2017

Neuroprotective potential of exercise preconditioning in stroke.

Mohammad Rashedul Islam, Michael F Young, Christiane D Wrann

Abstract read
In one paragraph

Article in Conditioning medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Role of Regular Physical Activity in Neuroprotection against Acute Ischemia.International journal of molecular sciences · 2020
    Review
  10. The Contribution of Physical Exercise to Brain Resilience.Frontiers in behavioral neuroscience · 2020
    Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammad Rashedul IslamMassachussetts General Hospital and Harvard Medical School, 149 13 Street, Charlestown, MA 02129, USA.
Michael F YoungMassachussetts General Hospital and Harvard Medical School, 149 13 Street, Charlestown, MA 02129, USA.
Christiane D WrannMassachussetts General Hospital and Harvard Medical School, 149 13 Street, Charlestown, MA 02129, USA.

Funding

Molecular mechanisms of exercise benefits in synapse plasticity and cognitionR00NS087096 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WRANN, CHRISTIANE D. · 2017 to 2019
$745k
Molecular mechanisms of exercise benefits in synapse plasticity and cognitionK99NS087096 · NINDS · DANA-FARBER CANCER INST · PI WRANN, CHRISTIANE D. · 2014 to 2015
$223k
NINDS NIH HHS K99 NS087096NINDS NIH HHS R00 NS087096
6 · The paper itself

Abstract

Stroke is one of leading causes of mortality and morbidity in the world with limited availability of therapeutic intervention. Exercise has been shown to improve stroke functional outcome in different preclinical and clinical setup. Exercise preconditioning induced neuroprotection in preclinical stroke models is believed to be mediated through its ability to restore brain vasculature and blood brain barrier integrity, promote neurogenesis, and help fight against neuroinflammation and excitotoxicity. In this short review, we will summarize the molecular mechanisms of exercise preconditioning described in preclinical stroke studies. We will also discuss the neuroprotective effects of pre-ischemic exercise.

Indexed as

cognitionexercisephysical activitypreconditioningStroke

Identifiers

PMID30465042
PMCPMC6242281

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.