Evidence map›Paper›PMID 30465025›Full record

ArticleReactive oxygen species (Apex, N.C.)2018

Graphene Quantum Dots Potently Block Copper-Mediated Oxidative DNA Damage: Implications for Cancer Intervention.

Rachel E Li, Y Robert Li, Hong Zhu, Zhenquan Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reactive oxygen species (Apex, N.C.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Radiopharmacokinetics of Graphene Quantum Dots NanoparticlesCurrent topics in medicinal chemistry · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rachel E LiHolly Springs High School, Holly Springs, NC 27540, USA.
Y Robert LiDepartment of Pharmacology, Campbell University Medical School, Buies Creek, NC 27506, USA.
Hong ZhuDepartment of Physiology and Pathophysiology, Campbell University Medical School, Buies Creek, NC 27506, USA.
Zhenquan JiaDepartment of Pharmacology, Campbell University Medical School, Buies Creek, NC 27506, USA.
Campbell University · USVirginia Tech · US

Funding

Cruciferous Dithiolethiones for Chronic Heart Failure: Signaling MechanismsR15CA192936 · NCI · CAMPBELL UNIVERSITY · PI LI, YUNBO · 2014 to 2014
$469k
Novel Carbon Nanodots against Vascular InflammationR15HL129212 · NHLBI · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JIA, ZHENQUAN · 2016 to 2016
$455k
Activating Multiorgan Antioxidative Gene Network for Treating SepsisR15GM124652 · NIGMS · CAMPBELL UNIVERSITY · PI ZHU, HONG · 2018 to 2018
$447k
NCI NIH HHS R15 CA192936NHLBI NIH HHS R15 HL129212NIGMS NIH HHS R15 GM124652
6 · The paper itself

Abstract

Our early work suggested that graphene quantum dots (GQDs) block Cu(II)/Cu(I) redox cycle in biological systems. Here we report that GQDs could also potently protect against copper redox-mediated oxidative DNA damage. Using Cu(II)/hydrogen peroxide, Cu(II)/hydroquinone, and Cu(II)/ascorbic acid as three biologically relevant systems for inducing oxidative DNA damage, we demonstrated that GQDs protected against the above system-induced DNA strand breaks in ϕx-174 plasmid DNA in a concentration-dependent manner. Notably, a significant protection was observed with GQDs at 1 μg/ml, and a nearly complete protection was shown with 10 and 100 μg/ml of GQDs. Using electron paramagnetic resonance (EPR) spectrometry in conjunction with α-(4-pyridyl-1-oxide)-

Indexed as

Ascorbic acidCopperDNA strand breaksElectron paramagnetic resonanceGraphene quantum dotsHydrogen peroxideHydroquinoneHydroxyl radicalNanotechα-(4-pyridyl-1-oxide)-N-tert-butylnitrone

Identifiers

PMID30465025
PMCPMC6242347
OpenAlexW2896875606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.