Evidence map›Paper›PMID 30465019›Full record

ArticleOptica2018

Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery.

Missael Garcia, Christopher Edmiston, Timothy York, Radoslav Marinov, Suman Mondal, Nan Zhu, Gail P Sudlow, Walter J Akers, Julie Margenthaler, Samuel Achilefu and 4 more

Abstract read
In one paragraph

Article in Optica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Advancements in Intraoperative Imaging for Enhanced Surgical Precision.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Advanced visual components inspired by animal eyes.Nanophotonics (Berlin, Germany) · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Missael GarciaDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
Christopher EdmistonDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
Timothy YorkDepartment of Electrical and Computer Engineering, Southern Illinois University at Edwardsville, Edwardsville, Illinois 62025, USA.
Radoslav MarinovDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
Suman MondalDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nan ZhuCollege of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Gail P SudlowDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Walter J AkersDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Julie MargenthalerDepartment of Surgery, Washington University School of Medicine, Barnes-Jewish Hospital and the Alvin J. Siteman Cancer Center, St. Louis, Missouri 63110, USA.
Samuel AchilefuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Rongguang LiangCollege of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Mohamed A ZayedDepartment of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Marta Y PepinoDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Viktor GruevBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
THE ROLE OF PHOSPHOLIPOGENESIS IN DIABETIC PERIPHERAL ARTERIAL DISEASEK08HL132060 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2017 to 2021
$466k
NCATS NIH HHS UL1 TR002345NCI NIH HHS R01 CA171651NHLBI NIH HHS K08 HL132060
6 · The paper itself

Abstract

Image-guided surgery can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky and costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities for distinguishing cancerous from healthy tissue. Here we introduce an innovative design, comprising an artificial multispectral sensor inspired by the

Identifiers

PMID30465019
PMCPMC6241325

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.