ArticleAdvanced biomedical research2018
Comparison of Propofol and Ketamine Combination (Ketofol) and Propofol and Fentanyl Combination (Fenofol) on Quality of Sedation and Analgesia in the Lumpectomy: A Randomized Clinical Trial.
Article in Advanced biomedical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comprehensive systematic review of randomized controlled trials on anesthetic agents in children's upper gastrointestinal endoscopy: highlighting safety concerns and efficacy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Effect of esketamine on the EDBMC anesthesiology · 2024Trial
- Effective dose of propofol combined with a low-dose esketamine for gastroscopy in elderly patients: A dose finding study using dixon's up-and-down method.Frontiers in pharmacology · 2022Article
- Article
- Safety and Efficacy of Two Different Concentrations of Ketamine and Propofol Combinations in Cataract Surgery: A Double-blind Randomized Clinical Trial : Efficacy of Two Different Concentrations of Ketofol in Cataract Surgery.Galen medical journal · 2022Article
- Total intravenous anaesthesia with tumescent infiltration anaesthesia without definitive airway for early excision and skin grafting in a major burn - A prospective observational study.Indian journal of anaesthesia · 2020Article
- Procedural Sedation Using a Propofol-Ketamine Combination (Ketofol) vs. Propofol Alone in the Loop Electrosurgical Excision Procedure (LEEP): A Randomized Controlled Trial.Journal of clinical medicine · 2019Article
- Perioperative complications of pediatric otorhinolaryngological operations.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast lumpectomy is an integral part of the treatment of mammary masses in women. This study was conducted to evaluate and compare two-drug combinations of propofol-ketamine (PK) (ketofol) and propofol-fentanyl (PF) (fenofol) on quality of sedation and analgesia in lumpectomy. MATERIALS AND
methodsThis was a randomized, double-blind, clinical trial performed on 64 patients aged 15-70 years with breast cancer lumpectomy referred to Isfahan's Seyed Al-Shohada Hospital. Consequently, patients were divided into two groups of 32 patients, each group receiving PF combination or PK combination during anesthesia.
resultsThe patients in two groups, PF and PK, were compared in their sedation levels, severity of pain, and other variables. The mean arterial blood pressure, systolic blood pressure, and heart rate (HR) did not show any significant difference at the beginning of the study in the two groups, but the fenofol (PF) group had a significantly lower oxygen saturation than the ketofol (PK) group. The sedation level was significantly lower in the fenofol group than the ketofol group (
conclusionThe two combinations of ketofol and fenofol cause rapid, favorable, safe anesthetic with minimal side effects and hemodynamic effects but it may be a superior alternative to fenofol combination, in terms of respiratory depression.
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