ReviewPediatric health, medicine and therapeutics2018
Perforation risk in pediatric appendicitis: assessment and management.
Review in Pediatric health, medicine and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05511194 (Safety and Efficacy of Enhanced Recovery After Surgery Therapeutic Protocol for Complicated Appendicitis in Children), which is not on this map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Enhanced Recovery After Surgery Therapeutic Protocol for Complicated Appendicitis in Children
Who cites it
48 citing papers in PubMed, 100 citations in OpenAlex.
- Preoperative Inflammatory Markers and Sonographic Free Peritoneal Fluid in Relation to Histopathologically Confirmed Appendiceal Perforation in Children: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Impact of a diagnostic strategy for appendicitis in children with acute abdominal pain in primary care: study protocol for a hybrid type 1 cluster randomised controlled trial.Diagnostic and prognostic research · 2026Review
- Evaluation of Opioid Administrations After Laparoscopic Appendectomy in Pediatrics With Perforated Versus Non-perforated Appendicitis: A Retrospective Cohort Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Research on the construction of an artificial intelligence model for the early diagnosis of pediatric acute appendicitis: a single-center retrospective study based on complete blood count.BMC pediatrics · 2026Article
- Routine Biomarkers in Paediatric Appendicitis Stratification: Which Add Diagnostic Value? A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Hospitalization costs of pediatric acute appendicitis in Western Romania: a single-center retrospective study.Journal of medicine and life · 2026Article
- Nutritional Status as a Risk Factor for Appendiceal Perforation in Pediatric Acute Appendicitis: Systematic Review.Children (Basel, Switzerland) · 2026Review
- Differentiating Uncomplicated From Complicated Acute Appendicitis in Paediatric Patients With C-Reactive Protein and Imaging Findings-A Retrospective Single Centre Study in 1149 Patients.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Impact of pediatric obesity on abdominal surgery outcome: a narrative review.Frontiers in pediatrics · 2026Review
- Incidentally-detected nonspecific and unusual histopathological findings in childhood appendectomy specimens: a retrospective analysis of 2633 cases.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Article
- Acute appendicitis masquerading as food poisoning.Radiology case reports · 2025Article
- Comparison of the efficacy of carbapenems and cephalosporins for postoperative treatment of perforated appendicitis in children.World journal of gastrointestinal surgery · 2025Article
- Acute Appendicitis in a Pediatric Minority Population: Uncommon Presentations of a Common Disease.Cureus · 2025Article
- Review
- Article
- The Importance of the Neutrophil-Lymphocyte Ratio (NLR) and the Platelet-Lymphocyte Ratio (PLR) as Biomarkers for Differentiating Complicated and Uncomplicated Appendicitis.Diagnostics (Basel, Switzerland) · 2024Article
- Prophylactic surgical drain placement with irrigation reduces abscess formation in patients with severe, uncontained, perforated appendicitis.Pediatric surgery international · 2024Article
- Article
- Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children.BMC medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perforated appendicitis, as defined by a visible hole in the appendix or an appendicolith free within the abdomen, carries significant morbidity in the pediatric population. Accurate diagnosis is challenging as there is no single symptom or sign that accurately predicts perforated appendicitis. Younger patients and those with increased duration of symptoms are at higher risk of perforated appendicitis. Elevated leukocytosis, bandemia, high C-reactive protein, hyponatremia, ultrasound, and CT are all useful tools in diagnosis. Distinguishing patients with perforation from those without is important given the influence of a perforation diagnosis on the management of the patient. Treatment for perforated appendicitis remains controversial as several options exist, each with its indications and merits, illustrating the complexity of this disease process. Patients may be managed non-operatively with antibiotics, with or without interval appendectomy. Patients may also undergo appendectomy early in the course of their index hospitalization. Factors known to predict failure of non-operative management include appendicolith, leukocytosis greater than 15,000 white blood cells per microliter, increased bands, and CT evidence of disease beyond the right lower quadrant. In this review, the indications and benefits of each treatment strategy will be discussed and an algorithm to guide treatment decisions will be proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.