Evidence map›Paper›PMID 30464671›Full record

ArticleJournal of blood medicine2018

Hematological parameters in Ghanaian sickle cell disease patients.

Charles Antwi-Boasiako, Ivy Ekem, Mubarak Abdul-Rahman, Frederika Sey, Alfred Doku, Bartholomew Dzudzor, Gifty B Dankwah, Kate Hagar Otu, John Ahenkorah, Robert Aryee

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In one paragraph

Article in Journal of blood medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Evidence-based obstetric management of women with sickle cell disease in low-income countries.Hematology. American Society of Hematology. Education Program · 2022
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  20. Detection of BCL11A and HBS1L-MYB Genotypes in Sickle Cell Anemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charles Antwi-BoasiakoDepartment of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana, antwiboasiako@gmail.com.
Ivy EkemDepartment of Haematology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Mubarak Abdul-RahmanDepartment of Pathology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Frederika SeySickle Cell Clinic, Korle-Bu Teaching Hospital, Accra, Ghana.
Alfred DokuDepartment of Internal Medicine, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.
Bartholomew DzudzorDepartment of Medical Biochemistry, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Gifty B DankwahDepartment of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana, antwiboasiako@gmail.com.
Kate Hagar OtuDepartment of Nursing and Midwifery, Greenhills School of Health Sciences, Accra, Ghana.
John AhenkorahDepartment of Anatomy, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Robert AryeeDepartment of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana, antwiboasiako@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEffective treatment and management of sickle cell disease (SCD) has been a challenge in Africa over the years. Hematological parameters are very useful profiles in the effective management of the disease. However, there is scarcity of studies on the hematological parameters of SCD in Ghana. This study aimed at determining hematological parameters among SCD patients with vaso-occlusion, those in the steady state as well as healthy controls at a teaching hospital in Ghana. METHODOLOGY: This was a cross-sectional study involving a total of 628 subjects, including 148 HbAA controls, 208 HbSS patients in steady state, 82 HbSC patients in steady state, 156 HbSS patients in vaso-occlusive crises (VOC), and 34 HbSC patients in VOC. Venous blood sample was collected from all study participants. A full blood count was done within 2 hours of collection, and hemoglobin (Hb) concentration, packed cell volume, red blood cell (RBC) concentration, mean corpuscular Hb, mean cell volume, mean corpuscular Hb concentration, and white blood cells (WBC) and platelet (PLT) counts were recorded.

resultsWBC and PLT counts were significantly higher in both female and male patients with SCD, compared with their healthy counterparts (

conclusionThe SCD patients had lower Hb and RBC than the controls; however, higher PLT and WBC are noted in various status of SCD, possibly reflecting spleen effect in these patients. Further studies are needed to confirm these findings.

Indexed as

anemiafull blood countGhanahematological parameterssickle cell disease

Identifiers

PMID30464671
PMCPMC6217132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.