Evidence map›Paper›PMID 30464616›Full record

ArticleCancer management and research2018

MicroRNA-588 regulates invasion, migration and epithelial-mesenchymal transition via targeting EIF5A2 pathway in gastric cancer.

Xiaorong Zhou, Manli Xu, Yonghong Guo, Ling Ye, Limin Long, Haiqin Wang, Pan Tan, Meili Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. CD8 + T Cells in Gastrointestinal Cancer: a Perspective on Targeting MicroRNA.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Eukaryotic initiation factor 5A2 and human digestive system neoplasms.World journal of gastrointestinal oncology · 2019
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaorong ZhouDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Manli XuDepartment of Basic Medicine, Guizhou College of Health Professions, Tongren, Guizhou, 554300, China.
Yonghong GuoDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Ling YeDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Limin LongDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Haiqin WangDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Pan TanDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Meili XuDepartment of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China, doctormeili@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundmiRNAs are potential regulators of genes in many cancers. Here, we confirmed that the expression of miR-588 decreased in gastric cancer (GC) tissues and cells. MATERIALS AND

methodsSixty-seven GC tissues along with noncancerous tissues adjacent to them were included in the study. Quantitative real-time reverse transcription-PCR study was done to quantify the expression levels of mature miRNA. The expression of proteins was determined by Western blot and transwell chamber assay for invasion and migration studies. Immunohistochemical analysis and luciferase assay were done for evaluating the expression of epithelial-mesenchymal transition (EMT) markers and activity of EIF5A2, respectively. In vivo metastatic assay was done by injecting MGC-803 cells into nude mice.

resultsIn the 5-year predicted survival study of GC patients included in the study, we found that miR-588 acted as a specific prognostic marker. Overexpression of miR-588 resulted in suppression of cell invasion, migration and progression of EMT, whereas suppression of miR-588 inverted the effects in both in vivo and in vitro experiments. miR-588 retained EIF5A2 by directly binding to the 3'-UTR. EIF5A2 was overexpressed in GC tissue samples, and the expression of miR-588 was inversely correlated to the levels of EIF5A2. The impact of miR-588 on invasion, migration and progression of EMT may be partially due to miR-588-mediated alterations of EiF5A2.

conclusionOverall, the findings of the study suggest that miR-588 acts as a tumor suppressor by regulating the invasion, migration and EMT via EIF5A2 pathway, hence presenting miR-588 as a prognostic marker as well as a therapeutic target for GC.

Indexed as

EIF5A2EMTgastric cancermiR-588

Identifiers

PMID30464616
PMCPMC6215924
OpenAlexW2898779647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.