Evidence map›Paper›PMID 30464590›Full record

ArticleCancer management and research2018

Palliative gastrectomy plus chemotherapy versus chemotherapy alone for incurable advanced gastric cancer: a meta-analysis.

Pei Wu, Pengliang Wang, Bin Ma, Songcheng Yin, Yuen Tan, Wenbin Hou, Zhenning Wang, Huimian Xu, Zhi Zhu

Expression of concernErratum issuedAbstract read
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In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Pei WuDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Pengliang WangDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Bin MaDepartment of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Dadong District, Shenyang 110042, Liaoning Province, China.
Songcheng YinDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Yuen TanDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Wenbin HouDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Zhenning WangDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Huimian XuDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.
Zhi ZhuDepartment of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China, zhuzhi@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhether palliative gastrectomy combined with chemotherapy can improve the survival of patients with advanced gastric cancer remains controversial. We performed a meta-analysis to clarify whether palliative gastrectomy plus chemotherapy can benefit patients with incurable advanced gastric cancer and to explore the best candidates in this patient population.

methodsWe searched the literature systematically using electronic databases including PubMed, EMBASE, and the Cochrane Library. And HRs and their 95% CIs were used to express the results for overall survival (OS) and progression-free survival (PFS).

resultsOne randomized controlled trial with 175 patients and 12 cohort studies with 2,193 patients were analyzed. The pooled HR for OS (HR=0.43, 95% CI=0.29-0.65,

conclusionThe results of this meta-analysis indicated that palliative gastrectomy plus chemotherapy can improve OS for incurable advanced gastric cancer. In addition, analyses based on liver metastasis and peritoneal dissemination demonstrated the advantages of palliative gastrectomy plus chemotherapy. However, the PFS of incurable advanced gastric cancer with palliative gastrectomy plus chemotherapy was no better than that under chemotherapy alone.

Indexed as

advanced gastric cancerchemotherapypalliative gastrectomysurvival

Identifiers

PMID30464590
PMCPMC6208494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.